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EC number: 807-113-1 | CAS number: 3709-71-5
The dermal irritation potential of the test article was determined using EpiDerm reconstructed skin membranes. The study was conducted in compliance with OECD GLP regulations. The test method was based on OECD Guideline 439 (2013). Two in vitro skin irritation tests were performed. In both tests, skin membranes were topically exposed to the undiluted test substance for 60 minutes. In the second test, the skin membranes were covered with a glass slide immediately after application to prevent evaporation of the test substance. In both tests, viability of the epidermal cells was assessed using the MTT test after 42 hours of culture. Negative and positive controls were run in parallel. In both tests, all acceptance criteria were met and therefore the study was considered valid. The mean viability of the test article-exposed EpiDerm tissues was 98 +/- 5% and 97 +/- 5% compared to the negative control group, in the first and second test, respectively. Based on the results of the study, the test article did not present evidence of dermal irritation potential and is classified as a non-irritant.
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