Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report Date:
2002

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
Batch number: 9000441462
Purity 98.1%

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
4.4
Temp.:
35 °C
pH:
7
Details on results:
The determination was performed at 35'C , which is the temperature of the column. However, the value obtained can be considered to represent the value at an unspecified, probably ambient temperature.

Applicant's summary and conclusion

Executive summary:

The chromatogram shows one main peak at retention time 9.95 minutes, corresponding to a partition coefficient (log value of 4.4).

Therefore the partition coefficient n-octanol/ water of NEOFOLIONE: log Pow = 4.4.