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EC number: 257-840-8 | CAS number: 52314-67-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Dossier
- Author:
- OECD SIDS
- Year:
- 2 008
- Bibliographic source:
- OECD HPV Chemical programme,SIDS Dossier, approved at SIAM 27 (14-17 October 2008)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Principles of method if other than guideline:
- Murine local lymph node assay was conducted on groups of mice at various concentrations on the dorsum of both ears for test chemical Nonanoyl Chloride (CAS no: 764-85-2) to determine its sensitization potential.
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- Nonanoyl Chloride
- Cas Number:
- 764-85-2
- Molecular formula:
- C9H17ClO
- IUPAC Name:
- Nonanoyl Chloride
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Nonanoyl chloride
- Molecular formula: C9H17ClO
- Molecular weight: 176.685 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: O=C(CCCCCCCC)Cl
- InChI: 1S/C9H17ClO/c1-2-3-4-5-6-7-8-9(10)11/h2-8H2,1H3
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Nonanoyl chloride
- Molecular formula: C9H17ClO
- Molecular weight: 176.685 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: O=C(CCCCCCCC)Cl
- InChI: 1S/C9H17ClO/c1-2-3-4-5-6-7-8-9(10)11/h2-8H2,1H3
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- Various concentration (5%, 10% and 15%)
- No. of animals per dose:
- 3
- Details on study design:
- Nonanoyl chloride in acetone /olive oil was applied to groups of mice for 3 consecutive days in various concentrations on the dorsum of both ears. On day 5 after the first application mice are injected intravenously with [³H]thymidine. Subsequently [³H]thymidine activity was measured as a function of isotope incorporation in the draining atricular lymph nodes.
- Positive control substance(s):
- not specified
- Statistics:
- Chemicals, which provoke at least in one concentration, a 3-fold or greater increase in isotope incorporation compared with the vehicle controls are classified as potential sensitizers.
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- other: T/C ratio
- Value:
- 12.7
- Test group / Remarks:
- at 5% concentration
- Remarks on result:
- other: sensitizing
- Parameter:
- other: T/C ratio
- Value:
- 19.4
- Test group / Remarks:
- at 10% concentration
- Remarks on result:
- other: sensitizing
- Parameter:
- other: T/C ratio
- Value:
- 20.9
- Test group / Remarks:
- at 25% concentration
- Remarks on result:
- other: sensitizing
- Cellular proliferation data / Observations:
- Nonanoyl chloride revealed sensitizing properties in this test.
Any other information on results incl. tables
% Concentration |
5 |
10 |
25 |
T/C ratio |
12.7 |
19.4 |
20.9 |
Applicant's summary and conclusion
- Interpretation of results:
- other: sensitizing
- Conclusions:
- The test material Nonanoyl Chloride (CAS no: 764-85-2) was considered to be sensitizing in the Murine local lymph node assay performed according to OECD 429 Guideline.
- Executive summary:
Murine local lymph node assay was conducted on groups of mice at various concentrations on the dorsum of both ears for test chemical Nonanoyl Chloride (CAS no: 764-85-2) to determine its sensitization potential in accordance with OECD 429 Guideline.
Nonanoyl chloride in acetone /olive oil was applied to groups of mice for 3 consecutive days in various concentrations on the dorsum of both ears. On day 5 after the first application mice are injected intravenously with [³H]thymidine. Subsequently [³H]thymidine activity was measured as a function of isotope incorporation in the draining atricular lymph nodes. Chemicals, which provoke at least in one concentration, a 3-fold or greater increase in isotope incorporation compared with the vehicle controls are classified as potential sensitizers.
Since the chemicalNonanoyl chloride (CAS no: 764-85-2) revealed sensitizing properties in this test, it was considered to be sensitizing in the Murine local lymph node assay.
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