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Ecotoxicological information

Toxicity to birds

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Administrative data

Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EPA OPP 71-1 (Avian Acute Oral Toxicity Test)
Deviations:
yes
Remarks:
Verification of test conc., stability, and homogeneity in diluent not determined. Periodic analyses of water and feed for potential contaminants not performed according to GLP standards (done at certified laboratory and standard US EPA analytical methods)
Qualifier:
according to
Guideline:
EPA OPPTS 850.2100 (Avian Acute Oral Toxicity Test)
Deviations:
yes
Remarks:
Verification of test conc., stability, and homogeneity in diluent not determined. Periodic analyses of water and feed for potential contaminants not performed according to GLP standards (done at certified laboratory and standard US EPA analytical methods)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
- Purity: 99.2%
Dose method:
gavage
Analytical monitoring:
no
Vehicle:
yes
Remarks:
1% CMC aqueous solution

Test organisms

Test organisms (species):
Colinus virginianus

Study design

Post exposure observation period:
14 days
No. of animals per sex per dose and/or stage:
5
Control animals:
yes, concurrent vehicle
Nominal and measured doses / concentrations:
Nominal: 0, 292, 486, 810, 1350, and 2250 mg a.s./kg bw

Examinations

Reference substance (positive control):
no

Results and discussion

Effect levelsopen allclose all
Key result
Dose descriptor:
LD50
Effect level:
> 2 250 mg/kg bw
Conc. / dose based on:
act. ingr.
Basis for effect:
mortality
Remarks on result:
other: highest concentration tested
Key result
Dose descriptor:
NOEL
Effect level:
2 250 mg/kg bw
Conc. / dose based on:
act. ingr.
Basis for effect:
signs of toxicity
Remarks on result:
other: highest concentration tested

Applicant's summary and conclusion

Conclusions:
LD50 (Northern bobwhite): >2250 mg a.s./kg bw (highest concentration tested)
NOEL (Northern bobwhite): 2250 mg a.s./kg bw (highest concentration tested)
Executive summary:

The test substance was administered to fasted northern bobwhite quail (Colinus virginianus) in an acute oral toxicity study. The study was conducted according to EPA OPP 71-1 and EPA OPPTS 850.2100. Five male and five female bobwhites per dose received single oral nominal doses of 0, 292, 486, 810, 1350, and 2250 mg a.s./kg bw at a dose volume of 10 mL/kg bw in 1% CMC aqueous solution. Birds were observed for clinical signs of toxicity, body weight effects, and mortality for 14 days after dosing. Since there were no mortalities or signs of toxicity, no birds were examined for gross pathological changes. The acute oral LD50 value for northern bobwhite exposed to the test substance by single oral dose was >2250 a.s. /kg bw, the highest concentration tested. The no mortality and no-observed effect level was 2250 mg a.s./kg bw.