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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report Date:
1986

Materials and methods

Principles of method if other than guideline:
The solubility of the test substance was determined in the following organic solvents: Acetone, Acetonitrile, Ethanol, Hexane, Isopropanol, Methanol, Methylene chloride, Toluene, Xylene, and Ethyl acetate. In each case, a saturated solution was made, and the test substance concentration determined by HPLC.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
- Purity: 99.7%

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
acetone
Solubility:
1 600 other: ppm
Medium:
acetonitrile
Solubility:
830 other: ppm
Medium:
ethanol
Solubility:
170 other: ppm
Medium:
ethyl acetate
Solubility:
680 other: ppm
Medium:
other: hexane
Solubility:
< 5 other: ppm
Medium:
isopropanol
Solubility:
74 other: ppm
Medium:
methanol
Solubility:
350 other: ppm
Medium:
other: methylene chloride
Solubility:
3 900 other: ppm
Medium:
toluene
Solubility:
9 other: ppm
Medium:
other: xylene
Solubility:
10 other: ppm

Applicant's summary and conclusion

Conclusions:
The solubility of the test substance in the various solvents is as follows:
Acetone: 1600 ppm
Acetonitrile: 830 ppm
Ethanol: 170 ppm
Ethyl acetate: 680 ppm
Hexane: < 5 ppm
Isopropanol: 74 ppm
Methanol: 350 ppm
Methylene chloride: 3900 ppm
Toluene: 9 ppm
Xylene: 10 ppm
Executive summary:

The solubility of the test substance was determined in the following organic solvents: Acetone, Acetonitrile, Ethanol, Hexane, Isopropanol, Methanol, Methylene chloride, Toluene, Xylene, and Ethyl acetate. In each case, a saturated solution was made, and the test substance concentration determined by HPLC.

The solubilites in the various solvents is as follows:

Acetone: 1600 ppm

Acetonitrile: 830 ppm

Ethanol: 170 ppm

Ethyl acetate: 680 ppm

Hexane: < 5 ppm

Isopropanol: 74 ppm

Methanol: 350 ppm

Methylene chloride: 3900 ppm

Toluene: 9 ppm

Xylene: 10 ppm