Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From September 21,2016 to October 21,2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Test material form:
liquid

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
6
Temp.:
35 °C
pH:
7
Type:
log Pow
Partition coefficient:
6.6
Temp.:
35 °C
pH:
7

Applicant's summary and conclusion

Conclusions:
In the conditions of the test, the chromatograms of SINODOR CQ show 3 peaks with relative peak areas over 1% at average retention times of 5.05 minutes (1.4% relative peak area), corresponding to a partition coefficient (log value) of 3.5; 18.41 minutes (86.5 % relative peak area), corresponding to a partition coefficient (log value) of 6.0 and 27.92 minutes (12.1% relative peak area), corresponding to a partition coefficient (log value) of 6.6.
Therefore:
Partition coefficients n-octanol/water of SINODOR CQ:
log Pow = 3.5; 6.0* and 6.6 *

* Indicatice values, peaks are outside calibration domain.