Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 270-732-5 | CAS number: 68477-42-9 A complex combination of hydrocarbons obtained from extractive distillation of saturated and unsaturated aliphatic hydrocarbons usually ranging in carbon numbers from C3 through C5, predominantly C4. It consists of saturated and unsaturated hydrocarbons having carbon numbers predominantly in the range of C3 through C5, predominantly butenes and isobutylene.
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 2.21 mg/m³
- Most sensitive endpoint:
- carcinogenicity
DNEL related information
- Overall assessment factor (AF):
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 530 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 3
- Dose descriptor:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Acute/short term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Acute/short term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Workers - Hazard for the eyes
Additional information - workers
A DN(M)EL for acute effects should be derived if an acute hazard leading to acute toxicity (eg. C&L) has been identified and there is a potential for high peak exposures. This is not the case with members of this category.
The marker substances with the highest relative hazard potential were selected. Long term systemic effects are therefore defined by the carcinogenicity of 1,3-butadiene in humans and long term local effects by nasal lesions caused by 2-methylpropene in rats. The DN(M)ELs of 2.21 and 1530 mg/m3 are equivalent to 1 and 667 ppm respectively.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 0.066 mg/m³
- Most sensitive endpoint:
- carcinogenicity
DNEL related information
- Overall assessment factor (AF):
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 918 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 5
- Dose descriptor:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Acute/short term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Acute/short term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Acute/short term exposure
- Hazard assessment conclusion:
- no data available: testing technically not feasible
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
A DMEL for acute effects should be derived if an acute hazard leading to acute toxicity (eg. C&L) has been identified and there is a potential for high peak exposures. This is not the case with members of this category.
The marker substances with the lowest DN(M)ELs were selected for population effects as these are most protective. Long term systemic effects are therefore defined by the carcinogenicity of 1,3-butadiene in humans and long term local effects by nasal lesions caused by 2-methylpropene in rats. The DN(M)ELs of 0.0664 and 1530 mg/m3 are equivalent to 30 ppb and 400 ppm respectively.
The main use of hydrocarbon streams are as intermediates and monomers, hence exposure of the general population is likely to be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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