Registration Dossier
Registration Dossier
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EC number: 272-028-3 | CAS number: 68649-42-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- other: Secondary Literature
- Title:
- IUCLID DATASET
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID DATASET- EUROPEAN COMMISSION – European Chemicals Bureau, 18–FEB–2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- An ocular irritation test was conducuted on rabbits to assess the eye irritation potential of chemical Dialkyl(C1-C14)dithiophosphoric acid, zinc salt (CAS No: 68649-42-3) in accordance with OECD Guide–line 405 "Acute Eye Irritation/Corrosion".
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts
- EC Number:
- 272-028-3
- EC Name:
- Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts
- Cas Number:
- 68649-42-3
- Molecular formula:
- C28H60O4P2S4Zn
- IUPAC Name:
- Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Common name: Phosphorodithioic acid, O,O–di–C1–14–alkyl esters, zinc salts
- Molecular formula: C28H60O4P2S4Zn
- Molecular weight: 716.38 g/mol
- Smiles notation: [Zn+2].CCCCCCCOP(=S)([S-])OCCCCCCC.CCCCCCCOP(=S)([S-])OCCCCCCC
- InChl: 1S/2C14H31O2PS2.Zn/c2*1-3-5-7-9-11-13-15-17(18,19)16-14-12-10-8-6-4-2;/h2*3-14H2,1-2H3,(H,18,19);/q;;+2/p-2
- Substance type: Organic
- Physical state: liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Common name: Phosphorodithioic acid, O,O–di–C1–14–alkyl esters, zinc salts
- Molecular formula: C28H60O4P2S4Zn
- Molecular weight: 716.38 g/mol
- Smiles notation: [Zn+2].CCCCCCCOP(=S)([S-])OCCCCCCC.CCCCCCCOP(=S)([S-])OCCCCCCC
- InChl: 1S/2C14H31O2PS2.Zn/c2*1-3-5-7-9-11-13-15-17(18,19)16-14-12-10-8-6-4-2;/h2*3-14H2,1-2H3,(H,18,19);/q;;+2/p-2
- Substance type: Organic
- Physical state: liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 100%
- Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- 24, 48, and 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM: according to the Draize scale.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- The undiluted material met the Annex VI (R36) criteria for irritation.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The test material Dialkyl(C1-C14)dithiophosphoric acid, zinc salt (CAS No: 68649-42-3) was considered to be irritating to the eyes of rabbits.
- Executive summary:
An ocular irritation test was conducuted on rabbits to assess the eye irritation potential of chemical Dialkyl(C1-C14)dithiophosphoric acid, zinc salt (CAS No:68649-42-3) in accordance with OECD Guide–line 405 "Acute Eye Irritation/Corrosion".
The undilutedDialkyl(C1-C14)dithiophosphoric acid, zinc saltwas administered to group of 6 rabbits and then eyes were observed at 24, 48, and 72 hours following treatment. The ocular lesions were scored according to the Draize scale.
Since the undilutedDialkyl(C1-C14)dithiophosphoric acid, zinc saltmet the Annex VI (R36) criteria for
Irritation, the chemical materialDialkyl(C1-C14)dithiophosphoric acid, zinc salt (CAS No:68649-42-3) was considered to be irritating to the eyes of rabbits
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