Registration Dossier
Registration Dossier
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EC number: 222-123-0 | CAS number: 3353-69-3
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- other:
- Remarks:
- Supporting evidence for corrosive effects of trichlorosilanes following inhalation
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate OECD test guideline, with acceptable restrictions. The restrictions were that the control was HCl rather than air, and there was only one low concentration tested.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- Deviations:
- yes
- Remarks:
- control animals received HCl gas, rather than air, one low concentration used.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Trichloro(methyl)silane
- EC Number:
- 200-902-6
- EC Name:
- Trichloro(methyl)silane
- Cas Number:
- 75-79-6
- IUPAC Name:
- trichloro(methyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- Six hours
- Frequency of treatment:
- 5 days/week, for two weeks.
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
10 ppm
Basis:
other: target concentration
- Remarks:
- Doses / Concentrations:
12 ppm
Basis:
analytical conc.
- No. of animals per sex per dose:
- 10
- Control animals:
- other: 30 ppm HCl
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- >= 12 ppm
- Sex:
- male/female
- Basis for effect level:
- other: No clinical effects or deaths observed.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a two-week repeated dose inhalation toxicity study, which was comparable to OECD 412, and conducted to GLP, the NOAEC was greater than the single concentration of 12 ppm trichloro(methyl)silane that was tested.
- Executive summary:
In a two-week repeated dose inhalation toxicity study, which was comparable to OECD 412, and conducted to GLP, the NOAEC was greater than the single concentration of 12 ppm trichloro(methyl)silane that was tested.
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