Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-185-4 | CAS number: 632-79-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reported by the U.S. National Toxicology Program and published in the peer reviewed literature.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Reference Type:
- publication
- Title:
- Chemical mutagenesis testing in Drosophilia. III. Results of 48 coded compouonds tested for the National Toxicology Program.
- Author:
- Valencia et al.
- Year:
- 1 985
- Bibliographic source:
- Environ. Mutagen 7, 325-348.
Materials and methods
- Principles of method if other than guideline:
- See Valencia et al. (1985) Environ. Mutagen 7, 325-348.
- GLP compliance:
- yes
- Type of assay:
- somatic mutation and recombination test in Drosophila
Test material
- Reference substance name:
- Tetrachlorophthalic anhydride
- EC Number:
- 204-171-4
- EC Name:
- Tetrachlorophthalic anhydride
- Cas Number:
- 117-08-8
- IUPAC Name:
- 4,5,6,7-tetrachloro-2-benzofuran-1,3-dione
- Details on test material:
- see rat and mouse 13 week studies
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- other: Canton-S wild-type
- Sex:
- male
Administration / exposure
- Route of administration:
- other: abdominal injection
- Vehicle:
- saline or peanut oil
- Duration of treatment / exposure:
- single injection
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
o, 500 ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- see Valencia et al. 1985
- Control animals:
- yes, concurrent vehicle
Examinations
- Tissues and cell types examined:
- see Valencia et al. 1985
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results : negative
Tetrachlorophthalic anhydride, administered to males via abdominal injection, did not induce sex-linked recessive lethal mutations in the fruit fly. - Executive summary:
Tetrachlorophthalic anhydride, administered to males via abdominal injection, did not induce sex-linked recessive lethal mutations in the fruit fly.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
