Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Endpoint summary

Administrative data

Description of key information

The physical state:       Insulin aspart precursor is a solid at 20 C.

Melting point:       Melting point could not determined. Thermal transition/ decomposition at 192 -205 °C (read-across data)

Boiling point:       Could not be determined due to decomposition (read-across data)

Relative density:       About 1.342 at 20.1oC for dryed substance (read-across data)

Particle size distribution:       not relevant as only used in suspension

Vapour pressure:       4.9 x 10-6 Pa at 20oC or 25oC (read-across data)

Partition coefficient:       LogPow = approximately 0.4 (estimated at pH 7 .9 for aquaous solution; read-across data).

Water solubility:       very pH dependent with a solubility of about 43 g/L at pH 3.6 and 393 mg/L at pH 7.9. In the interval of pH 4.5-6.5 the substance can be considered as insoluble (read-across data).

Surface tension:       surface tension of a 90% saturated solution: 58.0 mN/m (read-across data)

Flash point:       negligible vapour pressure and consequently will not emit flammable vapours (Read-across data)

Auto-flammability:       No self-ignition observed when heated to 400 ºC (Read-across data)

Flammability:       not flammable (read-across data)

Explosiveness:       not explosive (read-across data)

Oxidising properties:       no chemical groups with oxidising properties in the molecule

Additional information