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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 806-984-5 | CAS number: 1392411-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 12, 2016 to December 16, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- DOC determination using a TOC analyser
- Details on sampling:
- At the start and at the end of the test, the content of the test substance in the test solutions was determined using DOC determination.
- Vehicle:
- no
- Details on test solutions:
- The water-accommodated fractions (WAF) were prepared for the test. This was done by weighing the respective nominal loads of the test substance, adding the corresponding amount of tap water and shaking vigorously for 23 h. The resulting solutions were filtered through 0.45 μm membrane filters. The real load of the test substance in mg/L were 4.6; 10.0; 22.0; 46.1; 100.1.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Specification: Species Danio rerio HAMILTON-BUCHANAN, Age: sexually immature young fish, length: 2 +/- 1 cm, Origin: The animals were obtained from a commercial supplier. Before being used for the test, the fish were kept for 12 d under test conditions. During this period, mortality did not surpass 5%. Supplier: Dehner Garten Center, 67433 Neustadt, Date of arrival: 19. October 2016.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- not specified
- Test temperature:
- 20.9 – 23.0°C
- pH:
- 7.8 - 8.1
- Dissolved oxygen:
- 8.3 - 9.7 mg/L
- Salinity:
- not specified
- Conductivity:
- not specified
- Nominal and measured concentrations:
- Nominal (mg/L): 4.6; 10.0; 22.0; 46.1; 100.1
Measured in t = 0 h and t = 96 h (mg/L) geometric mean: 2.3; 4.5; 6.3; 16.7; 33.3
Nominal and measured concentrations of the test substance in blank controls: 0 - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7.9 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the 96 h measured LC50 of the substance was determind to be 7.9 mg/L (equivalent to nominal level of 25 mg/L) (Muckle, 2017).
- Executive summary:
A study was conducted to determine the toxicity of the substance to Danio rerio according to OECD Guideline 203 and EU Method C.1, in compliance with GLP. Water-accommodated fractions (WAF) were prepared for the test. This was done by weighing the respective nominal loads of the test substance, adding the corresponding amount of tap water and shaking vigorously for 23 h. The resulting solutions were filtered through 0.45 μm membrane filters. The study was performed using 5 concentrations ranging from 4.6 to 100 mg/L nominal concentration. At the start and at the end of the test, the content of the test substance in the test solutions was determined using DOC determination. The determined test substance concentrations based on measurement of DOC ranged between 28 and 55% of the nominal concentration. The total exposure period was 96 h. The three top concentrations showed mortality between 14 and 100%. Under the study conditions, the 96 h measured LC50 of the substance was determined to be 7.9 mg/L (equivalent to a nominal level of 25 mg/L) (Muckle, 2017).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.9 mg/L
Additional information
A study was conducted to determine the toxicity of the substance to Danio rerio according to OECD Guideline 203 and EU Method C.1, in compliance with GLP. Water-accommodated fractions (WAF) were prepared for the test. This was done by weighing the respective nominal loads of the test substance, adding the corresponding amount of tap water and shaking vigorously for 23 h. The resulting solutions were filtered through 0.45 μm membrane filters. The study was performed using 5 concentrations ranging from 4.6 to 100 mg/L nominal concentration. At the start and at the end of the test, the content of the test substance in the test solutions was determined using DOC determination. The determined test substance concentrations based on measurement of DOC ranged between 28 and 55% of the nominal concentration. The total exposure period was 96 h. The three top concentrations showed mortality between 14 and 100%. Under the study conditions, the 96 h measured LC50 of the substance was determined to be 7.9 mg/L (equivalent to nominal level of 25 mg/L) (Muckle, 2017).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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