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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Testing was performed before OECD guideline published.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
name of testing material: 77-227 Hibiscolide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Preliminary study:
Acute oral toxicity in rates
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Mortality:
0

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
10 rats were used in the study. The animals were observed over a 14 day period for mortality and/or systemic effects. A gross necropsy was conducted on all animals.
The oral LD50 of 12-oxahexadecanolide in rats exceeded 5000 mg/kg with 0/10 deaths at that dose
Executive summary:

The oral LD50 of 12-oxahexadecanolide in rats exceeded 5000 mg/kg with 0/10 deaths at that dose.

Cevolide does not met the criteria for classication according the CLP Regulation (EC) No. 1272/2008.