Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 Nov to 22 Dec 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
Test material name (as stated in the report): Cervolide
Batch No.: VE00444960
Expiry date:June 06, 2018

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
4.4
Temp.:
35 °C
pH:
7
Details on results:
The determination was performed at 35°C (column temperature), however the values can be considered to represent the values at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Kow values were determined. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.

Applicant's summary and conclusion

Conclusions:
In the conditions of the test, the chromatograms of Cervolide show one peak at average retention times of 8.656 minutes, corresponding to a partition coefficient (log value) of 4.4.
Therefore:
Partition coefficient n-octanol/water of Cervolide: log Pow = 4.4
Executive summary:

The Partition Coefficient n-octanol/water of Cetonal was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD guideline No. 117.

In the conditions of the test, the chromatograms of Cervolide show one peak at average retention times of 8.656 minutes, corresponding to a partition coefficient (log value) of 4.4.

Therefore:

Partition coefficient n-octanol/water of Cervolide: log Pow = 4.4