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EC number: 279-919-6 | CAS number: 82205-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No data is available for the target substance. Thus, available data from a structural analogue (chloride salt) was used in a read-across approach. Details on the read-across rational are provided in section 13.
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD 422) the source substance was administered orally to 10 male and female Sprague-Dawley rats/dose in water by gavage at dose levels of 0, 40, 100, or 250 mg/kg bw/day. Based on the results of the present study, the NOAEL for maternal and reproductive/developmental toxicity was considered to be 250 mg/kg bw/day.
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 250 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No data is available for the target substance. Thus, available data from a structural analogue (chloride salt) was used in a read-across approach. Details on the read-across rational are provided in section 13.
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD 422) the source substance was administered orally to 10 male and female Sprague-Dawley rats/dose in water by gavage at dose levels of 0, 40, 100, or 250 mg/kg bw/day.
There were no treatment-related effects found regarding mortality, clinical signs, neurotoxicity assessment, body weights, food consumption, histopathology, organ weights, haematology and clinical chemistry. Concerning the reproductive parameters, no relevant differences were found in terms of mating performance including the pre-coital interval (number of days paired to sperm positive day), copulatory evidence (the positive identification of mating i.e. the presence of sperm and/or copulation plug in situ or in the cage) or fertility index. All pregnant females had a comparable length of gestation period and gave birth on day 22 post coitum (mean value). An increased incidence of pups loss value (percentage) on day 1 post partum and post natal loss value on day 4 post partum (percentage) was observed in females receiving 250 mg/kg bw/day without any dose-relationship. Sex ratios at birth and on day 4 post partum did not show differences between groups, when calculated as the percentage of males. Similar clinical signs were recorded in control and treated pups during the lactation period. At necropsy, pups of females receiving 250 mg/kg bw/day and sacrificed at termination showed an increased incidence of no milk in stomach. Deceased pups did not show relevant findings both in control and treated groups.
Based on the results of the present study, the NOAEL for maternal and reproductive/developmental toxicity was considered to be 250 mg/kg bw/day.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data from a structural analogue (chloride salt), the target substance does not warrant classification for reproductive toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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