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EC number: 201-184-7 | CAS number: 79-19-6
Weight of evidence: According the National Institute of Technology and Evaluation for the test substance tested in concentration 0. 0.4, 2 and 10 mg/kg the NOAEL and NOEL was assigned the value of 2 mg/kg since no changes attributed to the test substance were noted in the parental animals and test substance does not cause any abnormalities on the offspring. For the test substance tested in the concentration 0,0.2, 1 and 5 mg/kg, the NOAEL and NOEL value were judged to be 1 mg/kg since nursing failure of the dams, and increase in stillbirth and a decrease in viability indices on days 0 and 4 after birth were observed in the group of 5 mg/kg.No abnormalities were detected in parental animals nor in the offsprings in tested concentrations of Thiosemicarbazide.
Thiosemicarbazide was tested by oral route to rats in the doses 0, 0.4, 2 and 10 mg/kg/bw. Dosing period was 42 days far males, for satellite females 42 days and for females 14 days before mating to day 4 of lactation. There were used 12 male animals per group (5 for recovery), 12 females animals and 5 satellite females.According to the data obtained from the Nagtional Institute of Technology and Evualtion, the tested Thiosemicarabzide does not have effects to the reproductive parameters such as estrous cycle, copulation index, fertility index, delivery index, gestation length, numbers of corpora lutea or implantations, implantation index, gestation index, parturition, or maternal behavior of parents animals in tested concentrations. No general toxicity to maternal animals was observed. However, a significant reduction in the number of live offspring on day 4, as well live birth index and viability index on day 4 was noted. At the necropsy, there was noted jaundice in 1dead offspring, each in 2 and 10 mg/kg/bw.However the relation to the test substance was not clear, since no similar changes were noted in any other offspring. No changes attributed to the test item were noted in the number of offspring or live offspring at birth, sex ratio, clinical signs, external features, or body weights. Based on this data, to NOAEL and NOEL value was assigned the value 2.0 mg/kg/bw.
Thiosemicarbazide was tested by oral route to rats in the doses 0, 0.2, 1 and 5 mg/kg/bw. Dosing period was 42 days far males, for satellite females 42 days and for females 14 days before mating to day 4 of lactation. There were used 12 male animals per group (5 for recovery), 12 females animals and 5 satellite females.According to the data obtained from the Nagtional Institute of Technology and Evualtion, an increase in whole litter loss and the decrease in viability index on postnatal day 4 in the next generation caused by nursing failure of the dams were observed in the groups of 5 mg/kg. No general toxicity to the maternal aniamls was observed.The tested Thiosemicarabzide does not have effects to the reproductive parameters such as estrous cycle, copulation index, the number of corpora lutea, number of implantation sites or gestation length in parental animals in tested concentrations. Based on this data, to NOAEL and NOEL value was assigned the value 1 mg/kg/bw.
The substance can not be classified for toxicity to reproduction according to CLP Regulation (EC) no. 1272/2008 due to insufficient data.
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