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EC number: 201-184-7 | CAS number: 79-19-6
Weight of evidence: According the several handbooks and the well documented publications the test item has the following LD values: LD50 oral value of 9.2 mg/kg/ for rats (Enviromental data on Organic chemicals) and 13 mg/kg/bw for rats (Merck Index). The ALD of 94 mg/kg for deer mouse (Archives of Environmental Contamination and Toxicology) and LD100 of 20 mg/kg for mice (Sage Journal). The LD50 of 10 mg/kg/bw for dog, LD50 of 20 mg/kg/bw for cat and LD50 of 94 mg/kg/bw for mouse were evaluated according the handbook of Envirnmental data on organic chemicals. In the summary, the different LD50 values are between 9.2 - 20 mg/kg for species (rats,mouse, cat and dog).
According the handbook of Enviromental data on Organic chemicals, the test item has an LD50 oral value of 9.2 mg/kg/bw for rats.
According the Merck index, the test item has an LD50 oral value of 13 mg/kg/bw for rat.
According the present publication,test item was tested for acute oral toxicity to deer mice. Based on the data from repellency test, the food reduction value, FR value, of thiosemicarbazide was evaluated between 74.7-88.0 %. In the test for acute oral toxicity, 6 animals were used. Animals were administrated by gavage using water, corn oil or 1.0 carbopol, followed by 3 days of observations for mortality.The result value of the acute oral toxicity approximate lethal dose ALD is 94 mg/kg and LDfr was evaluated as 317 mg/kg/bw.
According the present study test item was tested for acute oral toxicity in black mice. Animals were observed closely for 4 hours and again at 12 and 24 hour interval.The majority of death occurred within first 4 hours. As the fatal convulsion occurred in all tested animals (810), the LD100 of 20 mg/kg/bw was evaluated.
According the handbook of Enviromental data on Organic chemicals, the test item has an LD50 oral value of 20 mg/kg/bw for cats.
According the handbook of Enviromental data on Organic chemicals, the test item has an LD50 oral value of 10mg/kg/bw for dog.
Weight of evidence: Several secondary source and publications of Klimisch 3 and 4 (no data on the method) is available for Thiosemicarbazide. This results range from 9.2-20 mg/kg bw in different species (mouse, rat, cat dog). The most sensitive specie seems to be the rat with a LD50 of 9.2 mg/kg. This information leads to the classification of the substance as Acute oral toxicity Category 2, H302 according to CLP Regulation (EC) no. 1272/2008.
Based on the available data, the test item Thiosemicarbazide is classified according to CLP Regulation (EC) no. 1272/2008 as acutely toxic, Category 2 according the Lethal dose LD50 of 9.2 mg/kg/bw rat.
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