Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Key study: Test substance was tested for bioacumulation. Bioacumulation factor was found to be less than or equal to 3.8 - 4.2 L/kg in the concentration 0.4 mg/L and 39 L/kg in the concentration of 0.04 mg/L.

Additional information

Key study: According the OECD TG305 C and following GLP principles.

Semicarbazide hydrochloride was tested for bioacumulation in the fish species Cyrpinus Carpio.They were fed twice per week with pellets during the 6 weeks of treatment and allocated in water bowl. Before the test, the range finding study was carried out on the Rice fish (Oryziaslatipes, weighted 0.28 g) to find out the concentration of the test substance in the study. The evaluated LC 50 vale was LC50 (48 h)=80.1 mg/L. Test substance was dissolved. The solution was introduced into aquarium where fish were kept. The Dissolved oxygen concentration and temperature were analyzed. The concentrations of chemicals were analyzed and the bioconcentration factor was calculated. In the concentration of 0.4 mg/L of test substance, the BCF factor was less than or equal to 3.8 - 4.2 L/kg and in the concentration of 0.04 mg/L the BCF factor was 39 L/kg.