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EC number: 421-720-5 | CAS number: 18085-02-4
ECHA has provided a 28 day repeated dose study to rats via oral exposure. No studies assessing inhalation or dermal exposure are available.
Based on information provided by ECHA, the results of a 28 day repeated dose study include a NOAEL of 225 mg/kg/day based on effects observed in the pancreas of high dose animals. In animals that received 750 mg/kg/day effects were observed on bodyweight gain, food consumption, liver enzymes and increases in various organ weights. The main effect was observed in males receiving 750 mg/kg/day which included mild exocrine necrosis of the pancreas which may have been related to the change in liver enzymes ALP and ALAT.
The effects on bodyweight, food consumption, organ weights and evidence of minor clinical signs (e.g. decreased faeces) were all considered of low toxicological importance. The organ weight change was present with no evidence histopathologically of organ dysfunction. As the main effect observed in the pancreas was mild and only observed at a high dose (greater than the guidance cut-off values in Tables 3.9.2 and 3.9.3 of the CLP regulation) no classification for STOT RE effects in the pancreas are deemed appropriate in accordance with the CLP Regulation (EC No. 1272/2008, as amended).
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