1,2-diacetoxybut-3-ene

Dissociation constant

Link to relevant study record(s)

Reference

Endpoint:

dissociation constant

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 112 (Dissociation Constants in Water)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Dissociating properties:

yes

No.:

#1

pKa:

5.17

Temp.:

21.5 °C

Remarks on result:

other: Titration with NaOH

No.:

#2

pKa:

5.02

Temp.:

21.5 °C

Remarks on result:

other: Titration with NaOH

No.:

#3

pKa:

5.19

Temp.:

21.5 °C

Remarks on result:

other: Titration with NaOH

No.:

#4

pKa:

5.12

Temp.:

21.5 °C

Remarks on result:

other: Titration with NaOH

When the test substance was titrated 0.0967 N NaOH, one endpoint was detected.  When the same amount for the titrations performed using 0.0958 N HCl, no endpoint was detected.

Conclusions:

The estimated pKa value for the test substance was determined to be 5.1 log units.

Description of key information

pKa: 5.1 at 21.5C (OECD TG 112)

Key value for chemical safety assessment

pKa at 20°C:

5.1