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Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Dissociating properties:
yes
No.:
#1
pKa:
5.17
Temp.:
21.5 °C
Remarks on result:
other: Titration with NaOH
No.:
#2
pKa:
5.02
Temp.:
21.5 °C
Remarks on result:
other: Titration with NaOH
No.:
#3
pKa:
5.19
Temp.:
21.5 °C
Remarks on result:
other: Titration with NaOH
No.:
#4
pKa:
5.12
Temp.:
21.5 °C
Remarks on result:
other: Titration with NaOH

When the test substance was titrated 0.0967 N NaOH, one endpoint was detected.  When the same amount for the titrations performed using 0.0958 N HCl, no endpoint was detected.

Conclusions:
The estimated pKa value for the test substance was determined to be 5.1 log units.

Description of key information

pKa: 5.1 at 21.5C (OECD TG 112)

Key value for chemical safety assessment

pKa at 20°C:
5.1

Additional information

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