Registration Dossier
Registration Dossier
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EC number: 287-337-9 | CAS number: 85480-57-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Skin sensitisation:
A study was conducted to determine the skin sensitisation potential of the read-across substance, benzenesulfonic acid, C10 -13 -alkyl derivs., sodium salts, according to OECD Guideline 406, in compliance with GLP. Ten male and ten female Hartley guinea pigs were included in the experiement. The induction was first done by intradermal injection. Test animals were injected with 0.1 mL Freund Complete Adjuvant (FCA), 0.1 mL of 25% test substance in water, and 0.1 mL test substance in FCA in water (final concentration 25%). Control group was treated in a similar manner with only FCA and water. On Day 7, a second, epicutaneous challenge was done. 0.5 mL of test susbtance (25%) was placed on gauze, and then placed on the animals. The animals were then bandaged, and the test substance remained in contact for 48 h. Control animals were exposed to vehicle only. The challenge consisted of 0.2 mL of 12.5 % test substance placed on gauze, which was then placed on the test and control animals. Gauze containing only vehicle was placed on the left flank. The exposure lasted 24 h. Observations for irritation were made at 24 and 48 h after the end of exposure. Skin was scored for irritation using the Draize scale. No positive reactions were observed at any of the time points. Under the study conditions, the substance was not sensitizing to guinea pig skin (RBM, 1985).
Justification for classification or non-classification
Based on the results of the an in vivo study with the read-across substance, benzenesulfonic acid, C10 -13 -alkyl derivs., sodium salts in rabbits, no classification for skin sensitisation is warranted according to EU CLP (EC) 1272/2008 criteria.
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