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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviwed journal.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP
Author:
GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER
Year:
1994
Bibliographic source:
Chemosphere. Vol. 28, No. 12, pp. 2203.2236, 1994
Reference Type:
review article or handbook
Title:
7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Author:
BG Chemie
Year:
2000
Bibliographic source:
BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the eye irritation potential of the test substance 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5).
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Molecular formula: C10H9NO4S
Molecular weight: 239.25g/mol
Substance type: organic
Physical state: solid
Specific details on test material used for the study:
Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Molecular formula: C10H9NO4S
Molecular weight: 239.25g/mol
Substance type: organic
Physical state: solid

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
50 mg
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2

Results and discussion

Results of in vivo study
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No Irritation was observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
In an eye irritation study, approx. 50mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid was instilled into the eyes of the rabbits. No eye irritation was observed after 7 days. Hence the test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) can be considered non-irritant to rabbit eyes.
Executive summary:

An eye irritation test was conducted in rabbits for test chemical7-amino-4-hydroxy-2-naphthalenesulfonic acid(CAS No: 87-02-5) toassess the eye irritation potential.

 

In this study, 50 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was instilled into the conjunctival sac of 2 animalsandanimalswere observed for 7 days.

 

No eye irritation was observed after 7 days.Hence the test chemical 7-amino-4-hydroxy-2-naphthalenesulfonic acid(CAS No: 87-02-5)can be considered non-irritant to rabbit eyes.