2-amino-5-hydroxynaphthalene-1,7-disulphonic acid

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviwed journal.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP

Author:

GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER

Year:

1994

Bibliographic source:

Chemosphere. Vol. 28, No. 12, pp. 2203.2236, 1994

Reference 2

Reference Type:

review article or handbook

Title:

7-Amino-4-hydroxy-2-naphthalenesulfonic acid

Author:

BG Chemie

Year:

2000

Bibliographic source:

BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To assess the eye irritation potential of the test substance 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5).

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

7-amino-4-hydroxynaphthalene-2-sulphonic acid

EC Number:

201-718-9

EC Name:

7-amino-4-hydroxynaphthalene-2-sulphonic acid

Cas Number:

87-02-5

Molecular formula:

C10H9NO4S

IUPAC Name:

7-Amino-4-hydroxy-2-naphthalenesulfonic acid

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Molecular formula: C10H9NO4S
Molecular weight: 239.25g/mol
Substance type: organic
Physical state: solid

Specific details on test material used for the study:

Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Molecular formula: C10H9NO4S
Molecular weight: 239.25g/mol
Substance type: organic
Physical state: solid

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Test system

Vehicle:

unchanged (no vehicle)

Amount / concentration applied:

50 mg

Duration of treatment / exposure:

24 hours

Observation period (in vivo):

7 days

Number of animals or in vitro replicates:

2

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

7 d

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No Irritation was observed

Applicant's summary and conclusion

Interpretation of results:

other: not irritating

Conclusions:

In an eye irritation study, approx. 50mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid was instilled into the eyes of the rabbits. No eye irritation was observed after 7 days. Hence the test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) can be considered non-irritant to rabbit eyes.

Executive summary:

An eye irritation test was conducted in rabbits for test chemical7-amino-4-hydroxy-2-naphthalenesulfonic acid(CAS No: 87-02-5) toassess the eye irritation potential.

 

In this study, 50 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was instilled into the conjunctival sac of 2 animalsandanimalswere observed for 7 days.

 

No eye irritation was observed after 7 days.Hence the test chemical 7-amino-4-hydroxy-2-naphthalenesulfonic acid(CAS No: 87-02-5)can be considered non-irritant to rabbit eyes.