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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal and safety asessment report

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP
Author:
GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER
Year:
1994
Bibliographic source:
Chemosphere. Vol. 28, No. 12, pp. 2203.2236, 1994
Reference Type:
review article or handbook
Title:
7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Author:
BG Chemie
Year:
2000
Bibliographic source:
BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation test was performed on to the inner surface of ears to assess the skin irritation potential of the test substance 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) in two New Zealand White albino rabbits.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Molecular formula: C10H9NO4S
- Molecular weight: 239.25g/mol
- Smiles: c12c(cc(S(O)(=O)=O)cc1O)cc(N)cc2
- InChl): 1S/C10H9NO4S/c11-7-1-2-9-6(3-7)4-8(5-10(9)12)16(13,14)15/h1-5,12H,11H2,(H,13,14,15)
- Substance type: organic
- Physical state: solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Molecular formula: C10H9NO4S
- Molecular weight: 239.25g/mol
- Smiles: c12c(cc(S(O)(=O)=O)cc1O)cc(N)cc2
- InChl): 1S/C10H9NO4S/c11-7-1-2-9-6(3-7)4-8(5-10(9)12)16(13,14)15/h1-5,12H,11H2,(H,13,14,15)
- Substance type: organic
- Physical state: solid

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
Weight at study initiation: 3 – 4kg

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24 hours

Observation period:
7 days
Number of animals:
2 (1/sex)
Details on study design:
TEST SITE
Area of exposure: inner surface of ears
% coverage: Not mentioned
Type of wrap if used: under an adhesive
dressing
REMOVAL OF TEST SUBSTANCE
Washing (if done): the test substance was washed off with water and soap/vegetable oil.
Time after start of exposure: after the exposure period

SCORING SYSTEM: Not mentioned

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No Irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
In a skin irritation study, approx. 500 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was applied to the inner surface of the ears of 2 rabbits. No skin irritation was observed after 7 days. Hence the test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) can be considered non-irritant to rabbit skin.
Executive summary:

The skin irritation test was performed in 2 New Zealand White rabbits (male and female) to assess the skin irritation potency of test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) for the observation period of 7 days.

 

In this skin irritation study, approx. 500 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was applied to the inner surface of the ears of 2 rabbits. The test chemical was applied under an adhesive dressing for 24 hours.

 

At the end of the exposure period, the test substance was washed off with water and soap/vegetable oil. The observation period was 7 days.

 

No skin irritation was observed after 7 days.Hence the chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) can be considered non-irritant to rabbit skin.