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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from NTRL

Data source

Reference
Reference Type:
secondary source
Title:
Initial submission: Letter from Eastman Kodak Co to USEPA Regarding Basictoxicity of 3-methylaminopropylamine with Attachments and Cover Letter dated 9/4/92.
Author:
NTRL
Year:
1992
Bibliographic source:
OTS0555335, NTRL, dated 9/4/92

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute inhalation toxicity study of 3-Methylaminopropylamine in rats
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
SMILES:CNCCCN
Specific details on test material used for the study:
- Name of test material (as cited in study report): 3-Methylaminopropylamine
- Molecular formula (if other than submission substance): C4H12N2
- Molecular weight (if other than submission substance): 88.1528 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Mass median aerodynamic diameter (MMAD):
7.2 µm
Geometric standard deviation (GSD):
1.41
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: stainless steel and glass inhalation chambers
- Exposure chamber volume: 420 liters.
- Method of holding animals in test chamber: whole body
- Source and rate of air: Atmospheres were produced by passing air over the surface of the liquid contained in a three necked flask maintained at 35° C tor 61 mg/m and 50° C for 189.3, mg/m3 .
- Method of conditioning air:
- System of generating particulates/aerosols: Vapor laden air exiting the flask vas diluted at a T at which point a chemical or physical reaction occurred resulting in the production of an aerosol.
- Method of particle size determination: Royco Analyzer over the course or exposure resulted in a stable distribution with an aerodynamic mass median diameter of 7.2µm and geometric standard deviation of 1.41.
- Treatment of exhaust air:
- Temperature, humidity, pressure in air chamber:

TEST ATMOSPHERE
- Brief description of analytical method used: Approximately 82% of the particles was less than 10 um in diameter. Chamber concentrations were determined every 0.5 hour by gas chromatography of sample collected in midget impingers.
- Samples taken from breathing zone: yes

VEHICLE
- Composition of vehicle (if applicable):
- Concentration of test material in vehicle (if applicable):
- Justification of choice of vehicle:
- Lot/batch no. (if required):
- Purity:

TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.):

CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration:
Analytical verification of test atmosphere concentrations:
yes
Remarks:
by gas chromatography
Duration of exposure:
6 h
Remarks on duration:
not specified
Concentrations:
0.0, 0.61 and 189.3 mg/m3
No. of animals per sex per dose:
Total: 12
0.0 mg/m3 : 4
0.61 mg/m3 : 4
189.3 mg/m3 : 4
Control animals:
yes
Details on study design:
- Duration of observation period following administration: No data
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: Mortality was observed.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 189.3 mg/m³ air
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: No mortality observed
Mortality:
No mortality observed at 189.3 mg/m3
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LC50 was considered to be > 189.3 mg/m3 when rat was exposed with 3-aminopropylmethylamine by Whole body inhalation for 6 hours.
Executive summary:

The acute inhalation toxicity study, rat were exposed with 3-aminopropylmethylamine in the concentration of 0.0, 0.61 and 189.3 mg/m3by Whole body inhalation for 6 hours.No mortality observed at189.3 mg/m3. Therefore, LC50 was considered to be > 189.3 mg/m3when rat was exposed with3-aminopropylmethylamineby Whole body inhalation for 6 hours.