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EC number: 200-237-1
CAS number: 55-55-0
The dermal irritation potential of N-methyl-p-aminophenol sulphate was assessed in rabbits.The study was performed as per OECD 404 Guidelines. Doses of 0.5 ml of N-methyl-p-aminophenol sulphate at a concentration of 3% were placed on gauze pads and successively applied to a clipped area on the left flank (3 minutes), the anterior right flank (1 hour) and the posterior right flank (4 hours) of one New Zealand White male rabbit. Untreated skin served as a control. Because the dosage form was not irritating in the first animal, it was applied for 4 hours to the two additional animals. The treated sites were observed for signs of irritation at1, 24, 48 and 72 hours after removal of the dressing.
No cutaneous reactions were observed after 72 hours in the rabbits.
Hence,N-methyl-p-aminophenol sulphate can be considered not irritating to rabbit skin.
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