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EC number: 274-105-7
CAS number: 69762-08-9
The acute dermal toxicity of the substance
has been assayed following the testing procedures outlined into the OECD
guideline 402. The substance was administered, as paste, by occlusive
application on 6 rats; a single dose of 5000 mg/kg was given. Animals
were observed for the successive 14 days. Clinical diagnosis was focused
on observing the appearance of skin, hair, visible mucous and
nutritional status, mental activity, somatomotor activity, responses to
stimuli, focusing on sensibility and reactivity, lacrimation, functional
assessment of the respiratory, digestive, urogenital and circulation
system. At the end of the observation period, the surviving animals were
killed and dissected.
Throughout the experiment no clinical
symptoms of intoxication were observed. Visual check revealed that coat,
skin and visible mucous membranes appeared without abnormalities. It was
also found good nutritional status, normal mental and motor activity,
reactivity and sensibility. Functionality of the circulatory,
respiratory, digestive and urogenital apparatus resulted to be normal.
Subcutaneous tissue and muscle, head, neck, stomac and intestine did not
show macroscopic pathomorphological changes.
The LD50 resulted to be greater than 5000
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