Registration Dossier

Administrative data

Description of key information

Skin sensitisation: sensitising

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation, other
Type of information:
other: classification of constituents
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
ECHA database
Qualifier:
no guideline followed
Principles of method if other than guideline:
The classification of constituents of Cymbopogon Winterianus was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/serious eye damage.
GLP compliance:
no
Type of study:
other: calculation
Remarks on result:
other: Not relevant
Remarks on result:
other: not relevant
Remarks on result:
other: not relevant

The most important constituents with regard to skin sensitisation are 1,(+)-citronellal (CAS 2385-77-5), citronellol (CAS 1117-61-9) and geraniol (CAS 106-24-1), present at typical concentrations of 36.27%, 12.74% and 21.56% respectively. These are all classified as skin sensitiser (Skin Sens. 1 / H317).

Interpretation of results:
other: sensitising
Remarks:
based on CLP criteria
Conclusions:
The most important constituents are classified for skin sensitisation and are present well above the classification threshold of 1% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Cymbopogon Winterianus is also considered to be classified for skin sensitisation (Skin Sens. 1 / H317).
Executive summary:

The classification of constituents of Cymbopogon Winterianus was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/serious eye damage. The most importantconstituents with regard to skin sensitisation are 1,(+)-citronellal (CAS 2385-77-5), citronellol (CAS 1117-61-9) and geraniol (CAS 106-24-1), present at typical concentrations of 36.27%, 12.74% and 21.56% respectively. These are all classified as skin sensitiser (Skin Sens. 1 / H317) and are present well above the classification threshold of 1% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Cymbopogon Winterianus is also considered to be classified for skin sensitisation (Skin Sens. 1 / H317).

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The classification of constituents of Cymbopogon Winterianus was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/serious eye damage. The most important constituents with regard to skin sensitisation are 1,(+)-citronellal (CAS 2385-77-5), citronellol (CAS 1117-61-9) and geraniol (CAS 106-24-1), present at typical concentrations of 36.27%, 12.74% and 21.56% respectively. These are all classified as skin sensitiser (Skin Sens. 1 / H317) and are present well above the classification threshold of 1% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Cymbopogon Winterianus is also considered to be classified for skin sensitisation (Skin Sens. 1 / H317).

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available data, Cymbopogon winterianus should be classified as a skin sensitiser (Skin Sens. 1 / H317) in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).