Registration Dossier
Registration Dossier
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EC number: 294-954-7 | CAS number: 91771-61-8 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cymbopogon winterianus, Gramineae.
Endpoint summary
Administrative data
Description of key information
Skin sensitisation: sensitising
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation, other
- Type of information:
- other: classification of constituents
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- ECHA database
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The classification of constituents of Cymbopogon Winterianus was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/serious eye damage.
- GLP compliance:
- no
- Type of study:
- other: calculation
- Remarks on result:
- other: Not relevant
- Remarks on result:
- other: not relevant
- Remarks on result:
- other: not relevant
- Interpretation of results:
- other: sensitising
- Remarks:
- based on CLP criteria
- Conclusions:
- The most important constituents are classified for skin sensitisation and are present well above the classification threshold of 1% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Cymbopogon Winterianus is also considered to be classified for skin sensitisation (Skin Sens. 1 / H317).
- Executive summary:
The classification of constituents of Cymbopogon Winterianus was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/serious eye damage. The most importantconstituents with regard to skin sensitisation are 1,(+)-citronellal (CAS 2385-77-5), citronellol (CAS 1117-61-9) and geraniol (CAS 106-24-1), present at typical concentrations of 36.27%, 12.74% and 21.56% respectively. These are all classified as skin sensitiser (Skin Sens. 1 / H317) and are present well above the classification threshold of 1% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Cymbopogon Winterianus is also considered to be classified for skin sensitisation (Skin Sens. 1 / H317).
Reference
The most important constituents with regard to skin sensitisation are 1,(+)-citronellal (CAS 2385-77-5), citronellol (CAS 1117-61-9) and geraniol (CAS 106-24-1), present at typical concentrations of 36.27%, 12.74% and 21.56% respectively. These are all classified as skin sensitiser (Skin Sens. 1 / H317).
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The classification of constituents of Cymbopogon Winterianus was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/serious eye damage. The most important constituents with regard to skin sensitisation are 1,(+)-citronellal (CAS 2385-77-5), citronellol (CAS 1117-61-9) and geraniol (CAS 106-24-1), present at typical concentrations of 36.27%, 12.74% and 21.56% respectively. These are all classified as skin sensitiser (Skin Sens. 1 / H317) and are present well above the classification threshold of 1% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Cymbopogon Winterianus is also considered to be classified for skin sensitisation (Skin Sens. 1 / H317).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data, Cymbopogon winterianus should be classified as a skin sensitiser (Skin Sens. 1 / H317) in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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