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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
genetic toxicity in vivo
Remarks:
Type of genotoxicity: genome mutation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1973-1978
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited description of materials & methods

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1980

Materials and methods

Principles of method if other than guideline:
A total of 186 compounds were examined by short -term assays using rat bone marrow cells (chromosome aberrations in vivo) and silk worms.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
In the list of the 186 compounds, also succinic anhydride and maleic anhydride were present.The compounds tested were selected as known carcinogens, non-carcinogenic structural analogues of carcinogens, food additives widely used in Japan, drugs used in long-term clinical therapy and industrial intermediates with high annual productions in Japan.

Test animals

Species:
rat

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negativeResult of the rat bone marrow cells (chromosome aberrations in vivo) was negative - no genotoxic effects
Executive summary:

A total of 186 compounds were examined by short -term assays using rat bone marrow cells (chromosome aberrations in vivo) and silk worms.

Result of the rat bone marrow cells (chromosome aberrations in vivo) was negative - no genotoxic effects