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EC number: 203-570-0 | CAS number: 108-30-5
The test substance was tested for skin corrosion potential in an in vitro skin corrosion study (OECD 431).The positive control had a mean relative tissue viability of 9% after 3 minutes exposure. The absolute mean OD540 (optical density at 540 nm) of the negative control tissues was within the laboratory historical control data range. The maximum inter-tissue variability in viability between two tissues treated identically was less than 23% and the maximum difference in percentage between the mean viability of two tissues and one of the two tissues was less than 13%, indicating that the test system functioned properly.
Skin corrosion is expressed as the remaining cell viability after exposure to the test substance. The relative mean tissue viability obtained after 3-minute and 1-hour treatments with Succinic anhydride compared to the negative control tissues was 96% and 12%, respectively. Because the mean relative tissue viability for Succinic anhydride was below 15% after the 1-hour treatment, it is considered to be corrosive.
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