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EC number: 700-890-7 | CAS number: 503614-91-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 28 September 2016 to 23 November 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- other: Reference to the validated analytical method used for the quantification of the hydrolysis samples.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - The buffer solutions were filter-sterilised through a 0.2 µm FP 30/0.2 CA-S filter (Whatman) and transferred into sterile vessels.
- To exclude oxygen, nitrogen gas was purged through the solutions for 5 minutes.
- The substance was spiked to the buffer solutions at a target concentration of 2 mg/L using a spiking solution in acetonitrile.
- The spiking volume was < 1% of the sample volume; nominal concentrations were not corrected for the spiking volume.
- For each sampling time, duplicate sterile vessels under vacuum were filled with 6 mL test solution and placed in the dark in a temperature controlled environment.
- Samples for analysis were taken immediately after preparation (t=0) and after 5 days (Tier 1)
- Samples for analysis were taken immediately after preparation (t=0) and at several sampling points after t=0 (Tier 2).
- Samples taken from solutions with a temperature > 20°C were cooled to room temperature using running tap water.
- Blank buffer solutions containing a similar content of blank spiking solution (acetonitrile) were treated similarly as the test samples and analysed at t=0.
- The pH of the test solutions (except for the blanks) was determined at each sampling point. - Buffers:
- - Acetate buffer pH 4: aqueous solution of 16.7% 0.1 M sodium acetate and 83.3% 0.1 M acetic acid.
- Phosphate bffer pH 7: aqueous solution of 0.1 M potassium di-hydrogenphosphate adjusted to pH 7 using 10 N sodium hydroxide.
- Borate buffer pH 9: aqueous solution of 0.1 M boric acid and 0.1 M potassium chloride adjusted to pH 9 using 10 N sodium hydroxide.
- Type of water: tap water purified by a purification system - Details on test conditions:
- Tier 1 preliminary test at pH 4, 7 and 9 and 49.9 ± 0.1°C.
Tier 2 main study at pH 7 and 9 and different temperatures.
Actual pH and temp.:
-pH 6.9 - 7.0; 19.9 ± 0.3°C, 50.1 ± 0.3°C and 59.8 ± 0.4°C
-pH 9.0 - 9.1; 19.9 ± 0.3°C, 50.3 ± 0.1°C and 60.0 ± 0.1°C
- All solutions containing the substance were protected from light. - Duration:
- 793.75 h
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- 1.9 mg/L
- Remarks:
- initial conc. of duplicate samples: 1.90 and 1.90 mg/L
- Duration:
- 793.52 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.9 mg/L
- Remarks:
- initial conc. of duplicate samples: 1.91 and 1.92 mg/L
- Duration:
- 793.3 h
- pH:
- 7
- Temp.:
- 60 °C
- Initial conc. measured:
- 2 mg/L
- Remarks:
- initial conc. of duplicate samples: 1.93 and 1.98 mg/L
- Duration:
- 510.37 h
- pH:
- 9
- Temp.:
- 20 °C
- Initial conc. measured:
- 1.9 mg/L
- Remarks:
- initial conc. of duplicate samples: 1.86 and 1.87 mg/L
- Duration:
- 22.23 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.9 mg/L
- Remarks:
- initial conc. of duplicate samples: 1.86 and 1.87 mg/L
- Duration:
- 2.78 h
- pH:
- 9
- Temp.:
- 60 °C
- Initial conc. measured:
- 2 mg/L
- Remarks:
- initial conc. of duplicate samples: 1.95 and 1.95 mg/L. Concentrations were also analysed at t=73.8 h; because the obtained logarithms relative concentrations were < 0 these results were not used for the calculations.
- Number of replicates:
- Two
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- A degree of hydrolysis of ≥ 10% was observed at pH 7 after 5 days. As no substance was measured after 5 days at pH 9, this suggest complete hydrolysis of the compound. According to the guideline, the higher Tier test was required to determine the half-life time of the substance at pH 7 and pH 9.
A degree of hydrolysis of < 10% was observed at pH 4 after 5 day (half-life time at 25°C is > 1 year). No further tests were required at pH 4. - Test performance:
- RECOVERIES
- Recovery is the concentration analysed at t=0 relative to the nominal concentration.
- The mean recovery was calculated from duplicate samples.
- The mean recoveries at each pH and temperature (Tier 2) are shown below.
- The mean recoveries fell within the criterion range of 90-110%.
- Conclusion: the analytical method was adequate to support the hydrolysis study on the substance.
- Remark: The concentrations analysed in the test samples were not corrected for recovery. - Transformation products:
- not specified
- % Recovery:
- 95
- pH:
- 7
- Temp.:
- 20 °C
- Duration:
- 0 h
- % Recovery:
- 96
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 0 h
- % Recovery:
- 98
- pH:
- 7
- Temp.:
- 60 °C
- Duration:
- 0 h
- % Recovery:
- 93
- pH:
- 9
- Temp.:
- 20 °C
- Duration:
- 0 h
- % Recovery:
- 93
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 0 h
- % Recovery:
- 98
- pH:
- 9
- Temp.:
- 60 °C
- Duration:
- 0 h
- Key result
- pH:
- 4
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 265 d
- Remarks on result:
- other: DT50 at 25°C from the Arrhenius equation for 50°C and 60°C
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.009 h-1
- DT50:
- 3.2 d
- Remarks on result:
- other: DT50 at 25°C from the Arrhenius equation for 20°C, 50°C and 60°C
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.002 h-1
- DT50:
- 13 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 60 °C
- Hydrolysis rate constant:
- 0.006 h-1
- DT50:
- 4.6 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0.005 h-1
- DT50:
- 6.2 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.171 h-1
- DT50:
- 4.1 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 60 °C
- Hydrolysis rate constant:
- 0.428 h-1
- DT50:
- 1.6 h
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- No substance was detected in the blank buffer solutions.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Half-life time at 25°C and pH 4, pH 7 and pH 9 was determined to be > 1 year, 265 days and 3.2 days, respectively.
- Executive summary:
The rate of hydrolysis of the substance at pH values normally found in the environment (pH 4-9) was determined in a GLP-compliant study according to EC C.7, OECD 111 and EPA OPPTS 835.2120.
In the preliminary Tier 1 study, a degree of hydrolysis of < 10% was observed at pH 4 after 5 days at 50°C. This corresponds with a half-life time at 25°C of > 1 year. The substance can be considered hydrolytically stable at pH 4. In the preliminary Tier 1 study, hydrolysis of > 10% was determined at pH 7 and pH 9 after 5 days and 50°C. The Tier 2 study was therefore conducted at pH 7 and pH 9. The substance was shown to degrade by a pseudo-first order behaviour at 50 and 60°C (pH 7) and at 20, 50 and 60°C (pH 9). No hydrolysis occurred at pH 7 and 20°C. The half-life time at 25°C were determined from the Arrhenius equation. The half-life time at 25°C and pH 7 was determined to be 265 days. The half-life time at 25°C and pH 9 was determined to be 3.2 days.
Reference
Table: Preliminary test (Tier 1) results
pH code |
Sampling time |
Analysed concentration [mg/L] |
Degree of hydrolysis [%] |
Actual pH |
|
Individual |
Mean |
||||
|
|
|
|
|
|
pH 4 |
0 hours |
2.00 |
|
|
4.0 |
|
|
2.01 |
|
|
4.0 |
|
|
|
|
|
|
|
5 days |
1.91 |
4.8 |
4.4 |
4.0 |
|
|
1.93 |
3.9 |
|
4.0 |
|
|
|
|
|
|
pH 7 |
0 hours |
1.99 |
|
|
7.1 |
|
|
2.17 |
|
|
7.1 |
|
|
|
|
|
|
|
5 days |
1.45 |
30 |
30 |
7.0 |
|
|
1.47 |
29 |
|
7.0 |
|
|
|
|
|
|
pH 9 |
0 hours |
2.05 |
|
|
9.0 |
|
|
2.13 |
|
|
9.0 |
|
|
|
|
|
|
|
5 days |
not detected |
not applicable |
not applicable |
9.0 |
|
|
not detected |
not applicable |
|
9.0 |
Description of key information
The half-life time of the substance at 25°C and pH 4, pH 7 and pH 9 was determined to be > 1 year, 265 days and 3.2 days, respectively.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 265 d
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.