Registration Dossier

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
other: review article
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Review article

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission Flavouring Group Evaluation 2, Revision 1 (FGE.02Rev 1)
Author:
European Food Safety Authority
Year:
2008
Bibliographic source:
http://www.efsa.europa.eu/; The EFSA Journal (2008) 709-60
Report Date:
2007
Reference Type:
review article or handbook
Title:
Flavouring substances and natural sources of flavourings.
Author:
CoE (Council of Europe)
Year:
1992
Bibliographic source:
4th Ed. vol. I. Chemically defined flavouring substances. Council of Europe, partial agreement in the social and public health field. Strasbourg.
Reference Type:
review article or handbook
Title:
Evaluation of certain food additives and contaminants.
Author:
JECFA
Year:
1999
Bibliographic source:
Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 17-26 June 1997. WHO Technical Report Series, no. 884. Geneva.
Reference Type:
review article or handbook
Title:
First annual report on chemically defined flavouring substances.
Author:
SCF (Scientific Committee for Food)
Year:
1995
Bibliographic source:
May 1995, 2nd draft prepared by the SCF Working Group on Flavouring Substances (Submitted by the SCF Secretariat, 17 May 1995). CS/FLAV/FL/140-Rev.2. Annex 6 to Document III/5611/95, European Commission, Directorate-General III, Industry.

Materials and methods

Type of study / information:
The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (the Panel) is asked to advise the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Scientific Panel is asked to evaluate 47 flavouring substances in the Flavouring Group Evaluation 2, Revision 1 (FGE.02Rev1), using the procedure as referred to in the Commission Regulation (EC) No 1565/2000. These 47 flavouring substances belong to chemical groups 1 and 2, Annex I of the Commission Regulation (EC) No 1565/2000.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Methyl tetradecanoate
- CAS-No. of test material (as cited in study report): 124-10-7
- FL-No. of test material (as cited in study report):09.106

Results and discussion

Any other information on results incl. tables

According to the default MSDI ( Maximised Survey-derived Daily Intake) approach, the 47 flavouring substances in this group have intakes in Europe from 0.0012 to 6.7 µg/capita/day, which are below the threshold of concern value for a structural class I substance of 1800 µg/person/day.

MSDI for Methyl tetradecanoate: 54 µg/capita/day.

SCF status: Category 1 (Considered safe in use)

JECFA status: No safety concern (No safety concern at estimated levels of intake)

CoE status: Category B (Flavouring substance which can be used provisionally in foodstuffs)

Applicant's summary and conclusion