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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: 3,7-DIMETHYLOCTANYL ACETATE
Author:
Edited by D.L.J Opydke
Year:
1980
Bibliographic source:
Food and Cosmetics Toxicology, Volume 18, Issue 6, 1980, Page 673

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as per mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of the given test chemical in humans.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Name of test material (as cited in study report): Dihydrocitronellyl acetate
IUPAC name: 3,7-dimethyl-1-octyl acetate
Molecular formula: C12H24O2
Molecular weight: 200.32 g/mol
Smiles notation: C([C@@H](CCOC(C)=O)C)CCC(C)C
InChl: 1S/C12H24O2/c110(2)65711(3)891412(v4)13/h1011H,59H2,14H3
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of test material (as cited in study report): Dihydrocitronellyl acetate
IUPAC name: 3,7-dimethyl-1-octyl acetate
Molecular formula: C12H24O2
Molecular weight: 200.32 g/mol
Smiles notation: C([C@@H](CCOC(C)=O)C)CCC(C)C
InChl: 1S/C12H24O2/c110(2)65711(3)891412(v4)13/h1011H,59H2,14H3
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
other: humans
Strain:
not specified
Details on test animals and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Petrolatum
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Concentration (if solution): 8% in Petrolatum
Duration of treatment / exposure:
48 hours
Observation period:
48 hours
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
not irritating
Other effects:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The given test chemical was considered to be not irritating to humans after 48 hours exposure.
Executive summary:

A skin irritation study was performed by using the given test chemical in humans to assess the irritation potential. Test chemical was tested 8% in petrolatum on human volunteers in a 48 hours closed patch test. No indication of irritation was observed. Hence, the given test chemical was considered to be not irritating to humans after 48 hours exposure.