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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC, B1
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
421-830-3
EC Name:
-
Cas Number:
49805-30-3
Molecular formula:
C6H7NO
IUPAC Name:
2-azabicyclo[2.2.1]hept-5-en-3-one

Test animals

Species:
other: Rat (Sprague-Dawley)

Administration / exposure

Vehicle:
other: Distilled water

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 671 mg/kg bw
95% CL:
>= 547 - <= 925
Remarks on result:
other: Slope of the mortality curve: 7.4
Mortality:
Male: 320 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 800 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 320 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 800 mg/kg bw; Number of animals: 5; Number of deaths: 4
Clinical signs:
other: Signs of toxicity related to dose levels: Pilo-erection was observed in all rats within five minutes of dosing and throughout the remainder of Day 1. This persisted and was accompanied on Day 1 and/or later intervals by: abnormal body carriage, abnormal g
Gross pathology:
Effects on organs:
No treatment related macroscopic findings were observed for
rats which died during the study or which were killed on Day
15.

Applicant's summary and conclusion

Interpretation of results:
other: harmful