Registration Dossier
Registration Dossier
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EC number: 200-090-3 | CAS number: 51-34-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 24 March 1961
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Experimental design according to Everett (1956).
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Hyoscine
- EC Number:
- 200-090-3
- EC Name:
- Hyoscine
- Cas Number:
- 51-34-3
- Molecular formula:
- C17H21NO4
- IUPAC Name:
- (1R,2R,4S,5S,7S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 25
- Control animals:
- other: not required as Scopolomanine was used as one reference substance
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 275 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: other: effective dose (salivation, 50% of test animals): 0.09 mg/kg bw effective dose (tremor, 50% of test animals): 0.14 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- A LD50 value of 1275 mg/kg bw in mice was reported in a publication. As the report is not sufficiently documented the reliability is not assignable.
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