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EC number: 200-090-3 | CAS number: 51-34-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Remarks:
- inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-09-02 to 2015-09-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- Version / remarks:
- (1992)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): municipal wastewater treatment plant Breisgauer Bucht, 800 mg dry solids per litre (ratio between inoculum and test item (as TOC) is 4:1)
- Sampling date: 1 September 2015- Preparation of inoculum for exposure: activated sludge was washed twice by settling the sludge, decanting the supernatant and resuspending the sludge in aerated tap water
- Concentration of sludge: 3.6 g/L dry solid after 3 h drying at 105°C (mean of triplicate measurements) - Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 g/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition: about 1000 mL mineral medium, 47.5 ml stock solution (corresponding 200 mg/L TOC), 355 ml pre-washed activated sludge (3.6 g d.s./l), corresponding to a final concentration of 800 mg d.s./l, and a volume of 1600 mL was filled up with a corresponding amount of mineral medium
- Test temperature: 20.8 - 21.4°C
- pH: test vessels 6.3 -7.6, blank vessels 6.7 - 7.5, reference substance vessels 6.6 - 8.0
- pH adjusted: yes (1 molar NaOH)
- Aeration of dilution water: yes- Suspended solids concentration: 3.6 g d.s./l
- Continuous darkness: diffuse light
TEST SYSTEM
- Culturing apparatus: Because of the high toxicity of the test item 2000 mL gas wash bottles connected with 250 ml gas wash bottle filled with 200 ml deionised water was used to obtain a closed system and to avoid a contamination of the environment with aerosols.
- Number of culture flasks/concentration: 2, only 1 for toxicity control
- Method used to create aerobic conditions: humified pressured air supplied by aquarium pumps connected with gas-washed bottles and 1 ml glass pipettes
- Measuring equipment: temperature: minimum/maximum-thermometer; pH: pH electrode and pH-meter 330; DOC: differential method (TC/IC) with a total Carbon analyser; CO2: non-dispersive infrared gas analyser (NDIR)
- Test performed in closed vessels: yes
SAMPLING
- Sampling frequency: 0 h, 3 h, 2 d, 7 d, 14 d, 21 d, 27 d, 28 d after start
- Sampling method: 20 ml of supernatant medium and filtered (membrane filter 0.45 µm) and washed with deionised water and filtered medium
- Sample storage before analysis: DOC measurement was performed at once or samples were deep-frozen at -18°C in falcon flasks
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes - Reference substance:
- diethylene glycol
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- >= 97 - <= 98
- Sampling time:
- 28 d
- Remarks on result:
- other: DOC-elimination: 97-98% using total TOC as reference value, 98% using DOC after 3 hours as reference value
- Details on results:
- Due to the low degree of adsorption of the test item, the DOC-elimination can be attributed directly to biodegradation.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable, fulfilling specific criteria
- Conclusions:
- The test item Scopolamine is inherent biodegradable according to OECD 302 B.
Reference
Table 1: DOC-measurement
|
Scopolamin |
Diethylene glycol |
Tox-control |
Blank |
|||
|
Vessel 5 |
Vessel 6 |
Vessel 3 |
Vessel 4 |
Vessel 7 |
Vessel 1 |
Vessel 2 |
DOC test item [mg/L] |
6731 |
6731 |
506300 |
506300 |
|
|
|
Volume of the test vessel in ml |
1600 |
1600 |
1600 |
1600 |
|
|
|
Volume test item in ml/vessel |
47,5 |
47,5 |
1 |
1 |
|
|
|
Calculated DOC at test start [mg/L] |
200 |
200 |
316 |
316 |
516 |
|
|
|
|
|
|
|
|
|
|
0 d |
214,3 |
208,3 |
337,8 |
338,4 |
563,5 |
3,1 |
4,9 |
0,125 d |
233,4 |
209,1 |
336,2 |
337,9 |
559,9 |
5,6 |
5,2 |
2 d |
210,4 |
211,2 |
333,4 |
335,7 |
566,4 |
5,7 |
5,9 |
7 d |
28,3 |
30,7 |
197,3 |
122,3 |
347,9 |
7,4 |
6,7 |
14 d |
13,1 |
10,4 |
8,1 |
8,4 |
22,2 |
7,7 |
7,2 |
21 d |
11,0 |
11,8 |
8,8 |
9,2 |
12,3 |
7,4 |
5,3 |
27 d |
11,7 |
13,0 |
8,3 |
9,6 |
15,4 |
7,6 |
7,4 |
28 d |
12,1 |
13,5 |
9,2 |
9,2 |
15,5 |
6,7 |
7,2 |
Table 2: DOC-degradation [%] referred to 3-h value
|
Scopolamin |
Diethylene glycol |
Tox-control |
||
|
Vessel 5 |
Vessel 6 |
Vessel 3 |
Vessel 4 |
Vessel 7 |
0,125 d |
0 |
0 |
0 |
0 |
0 |
2 d |
10 |
-1 |
1 |
1 |
-1 |
7 d |
91 |
88 |
42 |
65 |
39 |
14 d |
98 |
99 |
100 |
100 |
97 |
21 d |
98 |
97 |
99 |
99 |
99 |
27 d |
98 |
97 |
100 |
99 |
99 |
28 d |
98 |
97 |
99 |
99 |
98 |
Table 3: DOC-degradation [%] referred to initial TOC
|
Scopolamin |
Diethylene glycol |
Tox-control |
||
|
Vessel 5 |
Vessel 6 |
Vessel 3 |
Vessel 4 |
Vessel 7 |
0 d |
-15 |
-3 |
-5 |
-6 |
-8 |
0,125 d |
-3 |
-3 |
-4 |
-5 |
-9 |
2 d |
89 |
88 |
39 |
63 |
34 |
7 d |
97 |
99 |
100 |
100 |
97 |
14 d |
98 |
97 |
99 |
99 |
99 |
21 d |
|
97 |
99 |
99 |
99 |
27 d |
98 |
97 |
100 |
99 |
98 |
28 d |
97 |
97 |
99 |
99 |
98 |
Elimination is referred to the calculated DOC at test start
Description of key information
The test item is considered to be inherent biodegradable according to OECD 302 B.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable, fulfilling specific criteria
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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