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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
other: expert assessment
Adequacy of study:
weight of evidence
Study period:
6 March 2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: An assessment was performed based on the Harmonised Classification and data on the acute dermal toxicity of the substance.

Data source

Reference
Reference Type:
other: expert assessment
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
An assessment was performed based on the Harmonised Classification and data on the acute dermal toxicity of the substance.
GLP compliance:
no
Test type:
other: An assessment was performed based on the Harmonised Classification and data on the acute dermal toxicity of the substance.
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexachlorocyclopentadiene
EC Number:
201-029-3
EC Name:
Hexachlorocyclopentadiene
Cas Number:
77-47-4
Molecular formula:
C5Cl6
IUPAC Name:
hexachlorocyclopentadiene

Results and discussion

Effect levels
Remarks on result:
other: An assessment was performed based on the Harmonised Classification and data on the acute dermal toxicity of the substance.
Mortality:
Hexachlorocyclopentadiene is to be considered as acute toxic by the dermal route and should be classified as Acute Tox. 3; H311.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
Hexachlorocyclopentadiene is to be considered as acute toxic by the dermal route and should be classified as Acute Tox. 3; H311.
Executive summary:

A Harmonised Classification as Acute Tox. 3; H311 (toxic in contact with the skin) is currently attributed to Hexachlorocyclopentadiene for the acute toxicity by the dermal route. This Harmonised Classification was translated from the Directive 67/548/EEC and should therefore be considered as a minimum classification unless there is evidence showing that the substance should be classified more severely.

Data was provided by the Lead Registrant on the acute toxicity of the substance by the dermal route.

A study was performed on Sprague-Dawley rats and concluded that the substance was not acutely toxic under the conditions of the test. This study is considered as reliable but does not allow revision of the Harmonised Classification as it would represent a less severe classification.

A study was performed on albino rabbits and concluded that the LD50 was below 200 mg/kg bw. This study is not considered as reliable due to significant deviations from the current OECD Testing Guidelines expected to lead to aggravated adverse effects and should not be used for the classification of the substance for its acute toxicity by the dermal route.

Additional data was provided by the EU (2007) as a secondary source but could not be accessed and assessed for their reliability.

No reliable data were available suggesting that Hexachlorocyclopentadiene should receive a more severe classification than the current Harmonised Classification as Acute Tox. 3; H311. In conclusion Hexachlorocyclopentadiene is to be considered as acute toxic by the dermal route and should be classified as Acute Tox. 3; H311. It is not considered relevant to perform an acute toxicity study on the substance by the dermal route.