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Diss Factsheets
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EC number: 201-029-3 | CAS number: 77-47-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: expert assessment
- Adequacy of study:
- weight of evidence
- Study period:
- 6 March 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on the Harmonised Classification and data on the acute dermal toxicity of the substance.
Data source
Reference
- Reference Type:
- other: expert assessment
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An assessment was performed based on the Harmonised Classification and data on the acute dermal toxicity of the substance.
- GLP compliance:
- no
- Test type:
- other: An assessment was performed based on the Harmonised Classification and data on the acute dermal toxicity of the substance.
- Limit test:
- no
Test material
- Reference substance name:
- Hexachlorocyclopentadiene
- EC Number:
- 201-029-3
- EC Name:
- Hexachlorocyclopentadiene
- Cas Number:
- 77-47-4
- Molecular formula:
- C5Cl6
- IUPAC Name:
- hexachlorocyclopentadiene
Constituent 1
Results and discussion
Effect levels
- Remarks on result:
- other: An assessment was performed based on the Harmonised Classification and data on the acute dermal toxicity of the substance.
- Mortality:
- Hexachlorocyclopentadiene is to be considered as acute toxic by the dermal route and should be classified as Acute Tox. 3; H311.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Hexachlorocyclopentadiene is to be considered as acute toxic by the dermal route and should be classified as Acute Tox. 3; H311.
- Executive summary:
A Harmonised Classification as Acute Tox. 3; H311 (toxic in contact with the skin) is currently attributed to Hexachlorocyclopentadiene for the acute toxicity by the dermal route. This Harmonised Classification was translated from the Directive 67/548/EEC and should therefore be considered as a minimum classification unless there is evidence showing that the substance should be classified more severely.
Data was provided by the Lead Registrant on the acute toxicity of the substance by the dermal route.
A study was performed on Sprague-Dawley rats and concluded that the substance was not acutely toxic under the conditions of the test. This study is considered as reliable but does not allow revision of the Harmonised Classification as it would represent a less severe classification.
A study was performed on albino rabbits and concluded that the LD50 was below 200 mg/kg bw. This study is not considered as reliable due to significant deviations from the current OECD Testing Guidelines expected to lead to aggravated adverse effects and should not be used for the classification of the substance for its acute toxicity by the dermal route.
Additional data was provided by the EU (2007) as a secondary source but could not be accessed and assessed for their reliability.
No reliable data were available suggesting that Hexachlorocyclopentadiene should receive a more severe classification than the current Harmonised Classification as Acute Tox. 3; H311. In conclusion Hexachlorocyclopentadiene is to be considered as acute toxic by the dermal route and should be classified as Acute Tox. 3; H311. It is not considered relevant to perform an acute toxicity study on the substance by the dermal route.
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