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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
other: Expert assessment
Adequacy of study:
weight of evidence
Study period:
2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: An assessment was performed based on available data on the toxicity of the substance to STP microorganisms identified in the European Union Risk Assessment Report on Hexachlorocyclopentadiene.
Qualifier:
no guideline followed
Version / remarks:
Expert assessment
Principles of method if other than guideline:
An assessment was performed based on available data on the toxicity of the substance to STP microorganisms identified in the European Union Risk Assessment Report on Hexachlorocyclopentadiene.
GLP compliance:
no
Key result
Duration:
0.5 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
inhibition of total respiration
Duration:
0.5 h
Dose descriptor:
EC10
Effect conc.:
100 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
inhibition of total respiration
Validity criteria fulfilled:
not applicable
Conclusions:
The reported endpoint results are: EC50 >100 mg/l and EC10 = 100 mg/l, both over a duration of 0.5 hours.
Executive summary:

An assessment was performed based on available data on the toxicity of the substance to STP microorganisms identified in the European Union Risk Assessment Report on Hexachlorocyclopentadiene.

A limited number of studies assessing the potential toxicity of hexachlorocyclopentadiene were identified in an EU risk assessment report on the substance (European Union, 2007). Of the reported studies only the OECD 209 study conducted by Desmares-Koopmans (2003) could be assessed as being relevant, reliable and adequate for the purposes of calculating the Predicted No Effect Concentration (PNEC) for microorganisms in STP and subsequent determination of the Risk Characterisation Ratio (RCR). The reported endpoint results from the Desmares-Koopmans (2003) study are: EC50 >100 mg/l and EC10 = 100 mg/l, both over a duration of 0.5 hours.

Description of key information

An assessment was performed based on available data on the toxicity of the substance to STP microorganisms. The most relevant and reliable study was performed by Desmares-Koopmans (2003) according to the OECD Testing Guideline 209. This study was considered as adequate for the purpose of calculating the Predicted No Effect Concentration (PNEC) for microorganisms in STP. The toxicity to STP microorganisms was reported by Desmares-Koopmans (2003) with an EC50 >100 mg/l and an EC10 = 100 mg/l, both over a duration of 0.5 hours.

Key value for chemical safety assessment

EC50 for microorganisms:
100 mg/L
EC10 or NOEC for microorganisms:
100 mg/L

Additional information