Registration Dossier
Registration Dossier
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EC number: 289-390-3 | CAS number: 88127-84-8
Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- density, other
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- 6 June 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- The density of the registered substance 9-[2-(2-methoxyethoxy)ethoxy]-9-[3(oxiranylmethoxy)propyl]- 2,5,8,10,13,16-hexaoxa-9-silaheptadecane was calculated using the US-EPA Toxicity Estimation Software Tool (T.E.S.T) (version 4.2) by T. Martin, U.S. EPA/National Risk Management Research Laboratory/Sustainable Technology Division, Cincinnati, OH 45268.
- Qualifier:
- no guideline required
- Version / remarks:
- US-EPA Toxicity Estimation Software Tool (T.E.S.T) (version 4.2) by T. Martin, U.S. EPA/National Risk Management Research Laboratory/Sustainable Technology Division, Cincinnati, OH 45268.
- Principles of method if other than guideline:
- Quantitative Structure Activity Relationships (QSARs) are mathematical models that are used to predict measures of toxicity from physical characteristics of the structure of chemicals (known as molecular descriptors). Acute toxicities (such as the concentration, which causes half of fish to die) are one example of toxicity measures, which may be predicted from QSARs. Simple QSAR models calculate the toxicity of chemicals using a simple linear function of molecular descriptors.
QSAR toxicity predictions may be used to screen untested compounds in order to establish priorities for expensive and time-consuming traditional bioassays designed to establish toxicity levels. When conditions do not permit traditional bioassays, QSARs are an alternative to bioassays for estimating toxicity. In addition, QSAR models are useful for estimating toxicities needed for green process design algorithms such as the Waste Reduction Algorithm.
The Toxicity Estimation Software Tool (T.E.S.T.) has been developed to allow users to easily estimate toxicity using a variety of QSAR methodologies. T.E.S.T allows a user to estimate toxicity without requiring any external programs. Users can input a chemical to be evaluated by drawing it in an included chemical sketcher window, entering a structure text file, or importing it from an included database of structures. Once a chemical has been entered, its toxicity can be estimated using one of several advanced QSAR methodologies. The program does not require molecular descriptors from external software packages (the required descriptors are calculated within T.E.S.T.).
T.E.S.T provides multiple prediction methodologies so one can have greater confidence in the predicted toxicities (assuming the predicted toxicities are similar from different methods). - GLP compliance:
- no
- Type of method:
- other:
- Key result
- Type:
- density
- Density:
- 1.08 g/cm³
- Temp.:
- 20 °C
- Conclusions:
- The density of the registered substance 9-[2-(2-methoxyethoxy)ethoxy]-9-[3(oxiranylmethoxy)propyl]- 2,5,8,10,13,16-hexaoxa-9-silaheptadecane was calculated using the US-EPA Toxicity Estimation Software Tool (T.E.S.T) (version 4.2) by T. Martin, U.S. EPA/National Risk Management Research Laboratory/Sustainable Technology Division, Cincinnati, OH 45268.
- Executive summary:
The density of the registered substance 9-[2-(2-methoxyethoxy)ethoxy]-9-[3(oxiranylmethoxy)propyl]- 2,5,8,10,13,16-hexaoxa-9-silaheptadecane was calculated using the US-EPA Toxicity Estimation Software Tool (T.E.S.T) (version 4.2) by T. Martin, U.S. EPA/National Risk Management Research Laboratory/Sustainable Technology Division, Cincinnati, OH 45268.
Reference
Description of key information
The density of the registered substance 9-[2-(2-methoxyethoxy)ethoxy]-9-[3(oxiranylmethoxy)propyl]- 2,5,8,10,13,16-hexaoxa-9-silaheptadecane was calculated using the US-EPA Toxicity Estimation Software Tool (T.E.S.T) (version 4.2) by T. Martin, U.S. EPA/National Risk Management Research Laboratory/Sustainable Technology Division, Cincinnati, OH 45268. The density was calculated to be 1.08 g/cm3
Key value for chemical safety assessment
- Relative density at 20C:
- 1.08
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
