Registration Dossier
Registration Dossier
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EC number: 240-968-3 | CAS number: 16919-19-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study completion date - 01 January 1988.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimental studies of the biological action of fluosilicic acid salts.
- Author:
- Rumyantsev, G.I.; Nóvikov, S.M.; Mélnikova, N.N.; Lévchenko, N.I.; Kóseva, E.E. and Kochetkova, T.A.
- Year:
- 1 988
- Bibliographic source:
- Gigiena i Sanitariya, (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- 53(11), 80,1988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- disodium;hexafluorosilicon(2-)
- Cas Number:
- 16893-85-9
- Molecular formula:
- Na2SiF6
- IUPAC Name:
- disodium;hexafluorosilicon(2-)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 70 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Details not available
- Clinical signs:
- other: - PERIPHERAL NERVE AND SENSATION: Flaccid paralysis without anesthesia (usually neuromuscular blockage); - BEHAVIORAL: Ataxia; - BEHAVIORAL: Muscle contraction or spasticity
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD50 for sodium hexafluorosilicate was found to be 70 mg/kg bw.
- Executive summary:
The acute oral toxicity of sodium hexafluorosilicate was evaluated in this study conducted with mice. The test substance was administered via drinking water. Flaccid paralysis resulting from neuromuscular blockage, ataxia and muscle contraction or spasticity were the clinical signs observed in this study. The study concluded that the LD50 for sodium hexafluorosilicate was 70 mg/kg bw.
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