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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer-reviewed data

Data source

Reference
Reference Type:
other: database
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
Deviations:
not applicable
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Target gene:
-
Species / strain
Species / strain / cell type:
S. typhimurium, other: TA 1535, TA 97, TA 98 and TA 100
Metabolic activation:
with and without
Test concentrations with justification for top dose:
Concentration: 0-333 µg/plate

Results and discussion

Test results
Species / strain:
S. typhimurium, other: TA 1535, TA 97, TA 98 and TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
no cytotoxicity
Positive controls validity:
valid

Applicant's summary and conclusion

Conclusions:
Under the conditions employed in the assay described in this report, the data suggest that the test article allyl alcohol shows no genetic toxicity.

Interpretation of results: negative.