Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
The toxicity of Allyl Alcohol
Author:
Dunlap MK, Kodama JK, Wellington JS, Anderson HH, Hine, CH
Year:
1958
Bibliographic source:
A.M.A. Archives of Industrial Health 18, 303-311

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
2-Propen-1-ol (0.5ml) was applied to intact and abraded skin (ventral surface) of 3 male albino rabbits. (It is not stated if fur at the treatment site was clipped first.) The application site was covered with gauze under a rubber dam, fastened with adhesive tape.
The test site was examined 24 hr post-application.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
exposure time: 24 h
Observation period:
no data
Number of animals:
3

Results and discussion

In vivo

Results
Irritation parameter:
erythema score
Basis:
other: animal #1 (of 3 animals)
Time point:
24 h
Reversibility:
fully reversible within: 48 h
Remarks on result:
other: Slight erythema was present at the application site (intact skin) of one animal.

Any other information on results incl. tables

Slight erythema was present at the application site (intact skin) of one animal when the patch was removed (24 hr timepoint) but this had fully resolved by 48 hr. No other reactions were noted.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Under the conditions of this test, 2-propen-1-ol was slightly irritating to rabbit skin.