Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
review article or handbook
Title:
Encyclopedia Of Toxicology, Four-Volume Set, Second Edition: 1-4
Author:
Philip Wexler
Year:
2005
Bibliographic source:
Encyclopedia Of Toxicology, Four-Volume Set, Second Edition: 1-4, Phylip Wexler, Academic Press, 2005

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
Swiss
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
1.5 mmol/kg
Control animals:
not specified

Results and discussion

Effect levels
Remarks on result:
other: development of hemolysis in ~50% of the animals

Applicant's summary and conclusion

Conclusions:
Intraperitoneal administration of 1.5 mmol/kg bw of allyl alcohol to starved Swiss albino mice causes the development of hemolysis in ~50% of the animals.
Other toxic effects include renal necrosis, pulmonary edema, and central nervous system effects at higher dose levels.