Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
The toxicity of allyl alcohol
Author:
Dunlap, M.K., Kodama, J.K., Wellington, J.S., Anderson, H.H., Hine, C.H.
Year:
1958
Bibliographic source:
AMA Archives of Industrial Health. 18:303-311

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not applicable
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): allyl alcohol
- Substance type: organic
- Physical state: liquid
- Analytical purity: 99%

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 h
Doses:
25 - 200 mg/kg bw
No. of animals per sex per dose:
3
Control animals:
not specified

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
Toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.
Executive summary:

Rabbits (3 males/group) were exposed for 24 hours to 25 - 200 mg/kg bw of 2-propen-1-ol (applied by injecting the 2-propen-1-ol though the occlusive dressing onto the surface of the skin and sealing the puncture site with rubber cement). Apathy, along with flushing of the skin, ataxia and diarrhoea were observed. On histopathological examination, toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.