Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
The toxicity of allyl alcohol
Author:
Dunlap, M.K., Kodama, J.K., Wellington, J.S., Anderson, H.H., Hine, C.H.
Year:
1958
Bibliographic source:
AMA Archives of Industrial Health. 18:303-311

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not applicable
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Analytical purity: 98.5%
- Impurities (identity and concentrations): diallyl ether and water

Test animals

Species:
rat
Strain:
Long-Evans
Sex:
male

Administration / exposure

Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 1 - <= 8 h
Concentrations:
95-5450 mg/m3 (nominal).
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
1 900 - 2 130 mg/m³ air
Based on:
test mat.
Exp. duration:
1 h
Sex:
male
Dose descriptor:
LC50
Effect level:
300 - 330 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Sex:
male
Dose descriptor:
LC50
Effect level:
140 - 150 mg/m³ air
Based on:
test mat.
Exp. duration:
8 h

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
Toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed.
The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively.
Executive summary:

Rats (Long-Evans; 6 males/group) were exposed for 1, 4 or 8 hours to allyl alcohol at concentrations between 95-5450 mg/m³ (nominal). Coma and diarrhoea were observed. On histopathological examination, toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed. The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively.