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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
other: database
Title:
Allyl Alcohol [CAS 107-18-6]
Author:
HSDB (Hazardous Substances Database), U.S. National Library of Medicine
Year:
2005
Bibliographic source:
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB
Reference Type:
publication
Title:
No information
Author:
Gorshtein ES et al
Year:
1978
Bibliographic source:
Eksp Med (Riga) 3: 15-20, cited in Ally Alcohol HSDB

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: no data
Deviations:
not specified
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Doses:
1 ml/100 g bw

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: cytochrome p450 increase, etc.
Effect level:
1 other: ml/100 g bw

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Acute Exposure/ Three hr after oral administration to rats of 1 ml/100 g body weight of allyl alcohol, cytochrome p450 was increased by 33% in liver microsomes. Aminopyrine demethylase and dimethylaniline demethylase were stimulated. Activity of microsomal hydroxylation system gradually decreased.