Allyl alcohol

Endpoint summary

Description of key information

- acute tox (oral, rat) LD50 = 64 mg/kg bw (Gardner 's Commercially Important Chemicals, 2005)
- acute tox (oral, rat) LD50 = 99 - 105 mg/kg bw (Dunlap, 1958)
- acute tox (oral, rabbit) LD50 = 72 mg/kg bw (Dunlap, 1958)

- acute tox (inhalation, 4h, rat) LC50 = 300 -330 mg/m³ (Dunlap, 1958)

- acute tox (dermal, rabbit) LD50 = 89 mg/kg bw (Dunlap, 1958)

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: peer-reviewed handbook

Qualifier:

according to guideline

Guideline:

other: no data

Deviations:

not specified

GLP compliance:

not specified

Test type:

other: no data

Species:

rat

Strain:

not specified

Sex:

not specified

Route of administration:

other: no data

Vehicle:

not specified

Control animals:

not specified

Dose descriptor:

LD50

Effect level:

64 mg/kg bw

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

LD5O (rat) = 64 mg/kg bw

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

64 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

not applicable

GLP compliance:

no

Species:

rat

Strain:

Long-Evans

Sex:

male

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

>= 1 - <= 8 h

Concentrations:

95-5450 mg/m3 (nominal).

No. of animals per sex per dose:

6

Control animals:

not specified

Sex:

male

Dose descriptor:

LC50

Effect level:

1 900 - 2 130 mg/m³ air

Based on:

test mat.

Exp. duration:

1 h

Sex:

male

Dose descriptor:

LC50

Effect level:

300 - 330 mg/m³ air

Based on:

test mat.

Exp. duration:

4 h

Sex:

male

Dose descriptor:

LC50

Effect level:

140 - 150 mg/m³ air

Based on:

test mat.

Exp. duration:

8 h

Interpretation of results:

Category 2 based on GHS criteria

Conclusions:

Toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed.
The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively.

Executive summary:

Rats (Long-Evans; 6 males/group) were exposed for 1, 4 or 8 hours to allyl alcohol at concentrations between 95-5450 mg/m³ (nominal). Coma and diarrhoea were observed. On histopathological examination, toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed. The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LC50

Value:

300 mg/m³ air

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

not applicable

GLP compliance:

no

Species:

rabbit

Strain:

not specified

Sex:

male

Type of coverage:

occlusive

Vehicle:

not specified

Duration of exposure:

24 h

Doses:

25 - 200 mg/kg bw

No. of animals per sex per dose:

3

Control animals:

not specified

Interpretation of results:

Category 2 based on GHS criteria

Conclusions:

Toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.

Executive summary:

Rabbits (3 males/group) were exposed for 24 hours to 25 - 200 mg/kg bw of 2-propen-1-ol (applied by injecting the 2-propen-1-ol though the occlusive dressing onto the surface of the skin and sealing the puncture site with rubber cement). Apathy, along with flushing of the skin, ataxia and diarrhoea were observed. On histopathological examination, toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

89 mg/kg bw

Justification for classification or non-classification

Acute toxicity oral: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 3; H 301: toxic if swallowed.

The CLP classification is in accordance with the one listed for allyl alcohol in Annex VI (EC No. 1272/2008).

Acute toxicity inhalation: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 2; H330: fatal if inhaled.

The CLP classification is a more severe classification than given in Annex VI (EC No. 1272/2008):

Category 3 (with an asterisk that indicates the minimum classification).

Acute toxicity dermal: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 2; H310: fatal in contact with skin.

The CLP classification is a more severe classification than given in Annex VI (EC No. 1272/2008):

Category 3 (with an asterisk that indicates the minimum classification).