Registration Dossier

Administrative data

Description of key information

- acute tox (oral, rat) LD50 = 64 mg/kg bw (Gardner 's Commercially Important Chemicals, 2005)
- acute tox (oral, rat) LD50 = 99 - 105 mg/kg bw (Dunlap, 1958)
- acute tox (oral, rabbit) LD50 = 72 mg/kg bw (Dunlap, 1958)

- acute tox (inhalation, 4h, rat) LC50 = 300 -330 mg/m³ (Dunlap, 1958)

- acute tox (dermal, rabbit) LD50 = 89 mg/kg bw (Dunlap, 1958)

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer-reviewed handbook
Qualifier:
according to
Guideline:
other: no data
Deviations:
not specified
GLP compliance:
not specified
Test type:
other: no data
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
other: no data
Vehicle:
not specified
Control animals:
not specified
Dose descriptor:
LD50
Effect level:
64 mg/kg bw
Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
LD5O (rat) = 64 mg/kg bw
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
64 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not applicable
GLP compliance:
no
Species:
rat
Strain:
Long-Evans
Sex:
male
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 1 - <= 8 h
Concentrations:
95-5450 mg/m3 (nominal).
No. of animals per sex per dose:
6
Control animals:
not specified
Sex:
male
Dose descriptor:
LC50
Effect level:
1 900 - 2 130 mg/m³ air
Based on:
test mat.
Exp. duration:
1 h
Sex:
male
Dose descriptor:
LC50
Effect level:
300 - 330 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Sex:
male
Dose descriptor:
LC50
Effect level:
140 - 150 mg/m³ air
Based on:
test mat.
Exp. duration:
8 h
Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
Toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed.
The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively.
Executive summary:

Rats (Long-Evans; 6 males/group) were exposed for 1, 4 or 8 hours to allyl alcohol at concentrations between 95-5450 mg/m³ (nominal). Coma and diarrhoea were observed. On histopathological examination, toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed. The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
Value:
300 mg/m³

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not applicable
GLP compliance:
no
Species:
rabbit
Strain:
not specified
Sex:
male
Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 h
Doses:
25 - 200 mg/kg bw
No. of animals per sex per dose:
3
Control animals:
not specified
Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
Toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.
Executive summary:

Rabbits (3 males/group) were exposed for 24 hours to 25 - 200 mg/kg bw of 2-propen-1-ol (applied by injecting the 2-propen-1-ol though the occlusive dressing onto the surface of the skin and sealing the puncture site with rubber cement). Apathy, along with flushing of the skin, ataxia and diarrhoea were observed. On histopathological examination, toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
89 mg/kg bw

Additional information

Justification for classification or non-classification

Acute toxicity oral: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 3; H 301: toxic if swallowed.

The CLP classification is in accordance with the one listed for allyl alcohol in Annex VI (EC No. 1272/2008).

Acute toxicity inhalation: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 2; H330: fatal if inhaled.

The CLP classification is a more severe classification than given in Annex VI (EC No. 1272/2008):

Category 3 (with an asterisk that indicates the minimum classification).

Acute toxicity dermal: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 2; H310: fatal in contact with skin.

The CLP classification is a more severe classification than given in Annex VI (EC No. 1272/2008):

Category 3 (with an asterisk that indicates the minimum classification).


Route: .live2