Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-003-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 22 June 2016 to 14 October 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Version / remarks:
- Organization for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline no. 112: "Dissociation Constants in Water" Adopted May, 12 1981.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7370 (Dissociation constants in water)
- Version / remarks:
- United States Environmental Protection Agency (EPA), Product Properties Test Guidelines no. OPPTS 830.7370: "Dissociation Constants in Water, August 1996.
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch: RC-1045Study specific test item informationPurity/composition correction factor: No correction factor requiredChemical name (IUPAC), synonym or trade name: Amides, tallow, N,N-bis(2-hydroxypropyl)CAS Number: 1454803-04-3Test item handling: No specific handling conditions required
- Dissociating properties:
- no
- Conclusions:
- Ingredients in MLA-3202 do not contain any groups that are ionised in the pH range 1-13.
- Executive summary:
The purpose of the study was to determine the physico-chemical properties for MLA-3202.
The dissociation constants of the test item was determined by Calculation method, in accordance with the following guidelines:
Organization for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline no. 112: "Dissociation Constants in Water" Adopted May, 12 1981.
United States Environmental Protection Agency (EPA), Product Properties Test Guidelines no. OPPTS 830.7370: "Dissociation Constants in Water, August 1996.
The pKa values calculated for C16:0 (palmitic) tallow amides, N-N-bis(2-hydroxypropyl) and C18:2 (linoleic) tallow amides, N-N-bis(2-hydroxypropyl), ingredients in MLA-3202 were calculated from their structure using Perrin’s calculation method. For this, a computer program was used. The operation of the computer program is described in the pKalc user's manual.
Since other ingredients in MLA-3202 have structures similar to that of C16:0 (palmitic) tallow amides, N-N-bis(2-hydroxypropyl) and C18:2 (linoleic) tallow amides, N-N-bis(2-hydroxypropyl), it is concluded that ingredients in MLA-3202 do not contain any groups that are ionised in the pH range 1-13.
Reference
Calculation method
Perrin’s calculation method was used to calculate the pKa values for the acidic and basic groups in C16:0 (palmitic) tallow amides, N-N-bis(2-hydroxypropyl), ingredients in MLA-3202.
Acidic groups Basic groups
RRCHOH 14.71 RCON(R)2 -0.70
15.76
Perrin’s calculation method was used to calculate the pKa values for the acidic and basic groups in C18:2 (linoleic) tallow amides, N-N-bis(2-hydroxypropyl), ingredients in MLA-3202.
Acidic groups Basic groups
RRCHOH 14.71 RCON(R)2 -0.70
15.76
Description of key information
Key value determined in a GLP accredited laboratory study in accordance with OECD Guideline 112 and US EPA Procedure OPPTS 830.7370.
Ingredients in MLA-3202 do not contain any groups that are ionised in the pH range 1-13.
Key value for chemical safety assessment
Additional information
The dissociation constants of the test item was determined by Calculation method.
The pKa values calculated for C16:0 (palmitic) tallow amides, N-N-bis(2-hydroxypropyl) and C18:2 (linoleic) tallow amides, N-N-bis(2-hydroxypropyl), ingredients in MLA-3202 were calculated from their structure using Perrin’s calculation method. For this, a computer program was used. The operation of the computer program is described in the pKalc user's manual.
Since other ingredients in MLA-3202 have structures similar to that of C16:0 (palmitic) tallow amides, N-N-bis(2-hydroxypropyl) and C18:2 (linoleic) tallow amides, N-N-bis(2-hydroxypropyl), it is concluded that ingredients in MLA-3202 do not contain any groups that are ionised in the pH range 1-13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.