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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB

P: The substance is not considered to be persistent

B: The Log octanol-water partition coefficient of the substance is -0.3 at 25.6 °C and pH 6 using the slow-stirring method (OECD 123). A BCF is calculated of 3.162 L/kg ww for the alkyl-dipropylene triamines and tripropylene tetramines assuming no metabolism. In vitro biotransformation by rainbow trout hepatic subcellulair fraction has been observed for primary alkyl amines and alkyl propane-1,3 -diamines. It is therefore likely that also alkyl dipropylene triamines and alkyl tripropylene tetramines are biotransformed. The calculated BCF indicates a low bioaccumulation potential.

T: The most sensitive species is daphnia magnafor which an EC10 of 712 µg/L has been derived from a 21 d study for tetramine C16-18 (CAS no 1219458-11-3). The study has been performed in natural surface water with a low DOC and suspended matter content. To compensate for possible mitigation by the surface water constituents the EC10 is divided by a factor of 10. As a worst-case it is thus assumed that 90% of the test substance was sorbed. Based on the Kpsusp of 100000 L/kg and a concentration of 15 mg/L suspended matter in surface waters, an adsorbed fraction of 43% is calculated

Based on the available ecotoxicity data it is concluded that the T criterion is not fulfilled for the tetramine C16-18, C18 unsaturated however based on the classification R48 the substance is to be classified as toxic.  

Likely routes of exposure:

The substance has a low vapour pressure, low water solubility and is cationic under environmental conditions and due to that sorbs strongly to soil, sediment and sludge.