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EC number: 266-042-9 | CAS number: 65997-13-9
Mean scores for corneal opacity, iris lesions, conjunctival redness and conjunctival edema (chemosis) were calculated for individual animals at 24, 48, and 72 hours after test substance application. Individual means are provided in the table below.
Individual Irritation Scores and Means at 24-, 48- and 72-Hours
This data is being read across from the source study that tested Resin acids and Rosin acids, hydrogenated, methyl esters based on category read across that is explained in the category justification document attached in Section 13 of the dossier.
In a primary eye irritation study, young adult New Zealand white rabbits (3 females) were exposed to 0.1 mL of undiluted Resin acids and Rosin acids, hydrogenated, Me esters in one eye. Animals were then observed for 7 days. Ocular reactions were scored according to the scale prepared by Draize (1944) for grading the severity of ocular lesions. The eyes of all rabbits were treated with fluorescein dye at 24 hours and examined. The test material caused minimal eye irritation which was completely reversible in seven days. Based on the results of this study, Resin acids and Rosin acids, hydrogenated, Me esters is not considered to be an eye irritant.
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