Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2005
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report Date:
2005

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
water
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
4 hr
Observation period:
24, 48, 72 Hr
Number of animals:
2

Results and discussion

In vivo

Results
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 4.2
Remarks on result:
probability of moderate irritation

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria