Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2005
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
α,4-dibromotoluene
EC Number:
209-636-5
EC Name:
α,4-dibromotoluene
Cas Number:
589-15-1
Molecular formula:
C7H6Br2
IUPAC Name:
α,4-dibromotoluene

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
water
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
4 hr
Observation period:
24, 48, 72 Hr
Number of animals:
2

Results and discussion

In vivo

Results
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 4.2
Remarks on result:
probability of moderate irritation

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria